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Projects / Programmes source: ARIS

Green technologies for processing of biomaterials

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Research activity

Code Science Field Subfield
2.02.00  Engineering sciences and technologies  Chemical engineering   

Code Science Field
T350  Technological sciences  Chemical technology and engineering 

Code Science Field
2.04  Engineering and Technology  Chemical engineering  
Keywords
Green Technologies, processing, biomaterials, carriers, active compounds, controlled release
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (19)
no. Code Name and surname Research area Role Period No. of publications
1.  14334  PhD Tonica Bončina  Materials science and technology  Researcher  2014 - 2017  402 
2.  27839  PhD Tanja Botić  Systems and cybernetics  Researcher  2014 - 2016  73 
3.  31616  PhD Maja Čolnik  Chemical engineering  Technical associate  2016 - 2017  132 
4.  21411  PhD Andrej Čretnik  Systems and cybernetics  Researcher  2014 - 2017  283 
5.  26446  PhD Barbara Dariš  Biochemistry and molecular biology  Researcher  2014 - 2017  57 
6.  33921  Tanja Fajfar  Chemical engineering  Researcher  2014 - 2017  0 
7.  22621  PhD Polonca Ferk  Metabolic and hormonal disorders  Researcher  2014 - 2017  142 
8.  38400  Katja Jerenec  Cardiovascular system  Researcher  2015 - 2017  0 
9.  02619  PhD Željko Knez  Chemical engineering  Head  2014 - 2017  2,049 
10.  21689  PhD Petra Kotnik  Chemical engineering  Researcher  2016 - 2017  157 
11.  25011  Marko Krainer  Chemical engineering  Technical associate  2014 - 2017  4 
12.  30607  PhD Elena Markočič  Chemical engineering  Researcher  2014 - 2015  60 
13.  13568  PhD Zoran Novak  Chemical engineering  Researcher  2014 - 2017  252 
14.  37786  PhD Jan Schmidt  Metabolic and hormonal disorders  Researcher  2015 - 2017  21 
15.  18987  PhD Andreja Sinkovič  Cardiovascular system  Researcher  2014 - 2017  589 
16.  11865  PhD Mojca Škerget  Chemical engineering  Researcher  2014 - 2017  776 
17.  32569  Maja Turičnik  Materials science and technology  Technical associate  2014 - 2015  11 
18.  33515  PhD Katja Vasić  Chemical engineering  Researcher  2016 - 2017  107 
19.  12295  PhD Franc Zupanič  Materials science and technology  Researcher  2014 - 2017  487 
Organisations (4)
no. Code Research organisation City Registration number No. of publications
1.  0334  University Medical Centre Maribor  Maribor  5054150000  23,266 
2.  0794  University of Maribor, Faculty of Chemistry and Chemical Engineering  Maribor  5089638012  13,275 
3.  0795  University ob Maribor, Faculty of mechanical engineering  Maribor  5089638010  24,202 
4.  2334  University of Maribor, Faculty of Medicine  Maribor  5089638048  16,045 
Abstract
Biomaterials were defined as materials foreign to the organism, used to repair, augment or substitute tissue and its functions (e.g implants, grafts, tissue engineering scaffolds, drug delivery systems etc.). The traditional methods for processing biomaterials involve high mechanical stress, high temperatures or hazardous volatile organic solvents. These methods may raise problems especially when processing drug formulations or when incorporating active compounds in the biomaterial. Supercritical fluids (SCF) (especially supercritical carbon dioxide (SC CO2)) may be used in material processing for particle production, microcellular foaming, impregnation, solvent extraction and material drying, or obtaining composites.   The proposed project would allow us to study the behavior of biomaterials (polymers, ceramic and composites) in the presence of SCF, to optimize the methods of processing these biomaterials by SCF technologies and to analyze the behavior of the obtained devices (foams, microparticles, aerogels) in systems that simulate their real life application. Moreover, we can evaluate the possibility of binding active compounds in / on biomaterials during or after processing, as well as achieving a prolonged and controlled release of drug.   The proposed project will be divided into 4 sections, namely: 1. Selection of appropriate biomaterials; 2. Processing biomaterials to obtain medical devices with specific properties; 3. Study of the suitability of the device for medical application; 4. Impregnation of biomaterials with active compounds and study of the controlled release of active compounds.   The main objective is to obtain a product with well characterized and well defined properties for practical use in medicine.   This project will represent a step forward in understanding the interactions between SCF and various biomaterials and active compounds and in using and managing these interactions in order to obtain products with desired properties. The knowledge obtained by the implementation of the research objectives in the context of the proposed project can be further applied to other materials and other systems, beyond the medical and pharmaceutical fields. The technologies developed with the help of SFC have globally proven as one of the most important sustainable technologies with almost zero impact to the environment.   By the participation of medical institutions, we gain access to specialized knowledge regarding the specific requirements for devices with application in medicine, which will benefit the research development and will allow a fast transfer of the products from design stage to practical use. Moreover, the collaboration between various European institutions specialized in various fields will allow the transfer of know-how, with short and long time benefits for all partners involved.   Research results will offer new fundamental knowledge in the fields of mass transfer, thermodynamic system characteristics, process optimization and scale-up. New data will be patented and published in journals with high impact factor. The new information will be also disseminated though the organization of workshops, which will offer all interested parties (both from the academic and industrial domain) an insight in a fast developing and highly promising field, hopefully opening the path for new national and international collaborations. Therefore, the project would enable know-how transfer, scientific growth and economic efficiency by supporting the implementation of sustainable technologies in Slovenia and EU.
Significance for science
SCF show high potential as environmentally friendly solvents for various applications. They have already proved their efficiency at industrial scale for extraction of valuable components from natural materials. However in other fields, such as biomaterials processing, foam or microparticles formation, research is still necessary to obtain the data needed to optimize and design the technologies. This project will represent a step forward in understanding the interactions between SCF and various biomaterials and active compounds and in using and managing these interactions in order to obtain products with desired properties. The aim is to obtain fundamental data regarding the phase behavior of different substances (polymer, composites or active compounds used for their impregnation) in the presence of SCF. These data are vital in process design, and all results will be published in the hope of contributing to the development of SCF applications in various scientific and industrial fields. Moreover, understanding the effect of processing methods on the physical characteristics, biostability and biological activity of the final products is essential when designing specific devices with specific applications, such as implants or tissue engineering scaffolds. The knowledge obtained by the implementation of the research objectives in the context of the proposed project can be later further applied to other materials and other systems, beyond the medical and pharmaceutical fields. The technologies developed with the help of SFC have globally proven as one of the most important sustainable technologies with almost zero impact to the environment.
Significance for the country
Modern medicine proves more concern for the patient’s comfort and compliance. Therefore extensive research is employed for improving effectiveness of drug carriers and of tissue engineering scaffolds. SCF may offer the possibility of optimizing such devices, leading to a better response of the organism to implants, a smaller risk of immune rejection or inflammation, in other words to faster healing without undesirable side effects. By the participation of medical institutions (MF UKC), we gain access to specialized knowledge regarding the specific requirements for devices with application in medicine, which will benefit the research development and will allow a fast transfer of the products from design stage to practical use. Moreover, the collaboration between various European institutions specialized in various fields will allow the transfer of know-how, with short and long time benefits for all partners involved. The extrapolation of the gained knowledge to other fields and a potential scale-up of the designed processes will offer new technologies with small impact to the environment and local knowledge for high added value products, marketed in Slovenia and worldwide. The use of unique characteristics of SCF (transportation characteristics, melting force, etc.) will increase the industrial competitiveness of Slovenia and at the same time create environmental and economic benefits for Slovenia and also for the EU. The use of SCF has as major advantage the possibility of processing different materials without the use of liquid organic solvents. This will bring both economic and environmental benefits: no organic solvents means no need of additional, expensive steps for removal, recovery or disposal of toxic solvent; the product will be solvent free, since SCF are completely removed from material by simple depressurization; there will be little environmental issues related to the energy consuming, high polluting processes of solvent purification or disposal, limiting the risk of pollution of air, soil, surface or underground water sources. The project aims to studying the basic elements which can lead to the development of such sustainable technologies. Research results will offer new fundamental knowledge in the fields of mass transfer, thermodynamic system characteristics, process optimization and scale-up. New data will be patented and published in journals with high impact factor. The new information will be also disseminated though the organization of workshops, which will offer all interested parties (both from the academic and industrial domain) an insight in a fast developing and highly promising field, hopefully opening the path for new national and international collaborations. Therefore, by continuing our research we will enable know-how transfer, scientific growth and economic efficiency by supporting the implementation of sustainable technologies in Slovenia and EU.
Most important scientific results Annual report 2014, 2015, final report
Most important socioeconomically and culturally relevant results Annual report 2014, 2015, final report
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