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Projects / Programmes source: ARIS

The textural analysis of spatiotemporal changes for breast lesions diagnosis on ultrafast breast MRIs

Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
B140  Biomedical sciences  Clinical physics, radiology, tomography, medical instrumentation 

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Keywords
Breast cancer, MR imaging, feature analysis, computer aided diagnostics (CADx)
Evaluation (rules)
source: COBISS
Researchers (16)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  30867  PhD Franci Bajd  Physics  Researcher  2014 - 2017  89 
2.  39533  PhD Blaž Banič  Biochemistry and molecular biology  Researcher  2017 
3.  33402  PhD Nina Bizjak  Physics  Researcher  2014  13 
4.  31188  PhD Olga Chambers  Mathematics  Junior researcher  2014  28 
5.  21745  MSc Kristijana Hertl  Oncology  Researcher  2015 - 2017  182 
6.  24570  PhD Maja Marolt Mušič  Oncology  Researcher  2015 - 2017  197 
7.  14574  PhD Mojca Urška Mikac  Physics  Researcher  2014 - 2017  151 
8.  32158  PhD Jana Milenković  Systems and cybernetics  Researcher  2014 - 2017  12 
9.  26530  PhD Andraž Perhavec  Medical sciences  Researcher  2015 - 2017  141 
10.  35603  Tina Robida    Technical associate  2014  16 
11.  37994  Katja Romarić    Technical associate  2015  15 
12.  07925  Ana Sepe    Technical associate  2014 - 2017  131 
13.  12056  PhD Igor Serša  Physics  Researcher  2014 - 2017  473 
14.  28490  PhD Jernej Vidmar  Cardiovascular system  Researcher  2014 - 2017  89 
15.  26268  PhD Andrej Vovk  Neurobiology  Researcher  2016 - 2017  53 
16.  12767  PhD Janez Žgajnar  Oncology  Head  2014 - 2017  354 
Organisations (4)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  91,855 
2.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  15,816 
3.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,703 
4.  1538  University of Ljubljana, Faculty of Electrical Engineering  Ljubljana  1626965  27,989 
Abstract
Early breast cancer (BC) detection and diagnostics is crucial for successful treatment of breast cancer (BC). In Slovenia, survival rate of patients with BC detected at an early stage, before it has spread to the regional lymph nodes, is more than 90%. Survival rate of patients with advanced stage of BC is lower and the treatment more expensive. Therefore, the timely and accurate detection and diagnostics of BC in its early stages is crucial for the prognosis of the disease. The main objective of the proposed research project is the development of interoperabile, independent CAD system to support helping the radiologist in the BC diagnosis, using ultra-fast MRI protocol, NMR spectroscopy (MRS), dynamic contrast-enhanced MRI (DCE-MRI) and MRI of the apparent diffusion constant (ADC mapping) for brest lesion characterization. MRS and MRI methods enable fast acquisition of the spectra of the various breast regions as well as acquisition and analysis of the contrast agent distribution dynamics inside the lesion. Furthermore, we want to confirm the accuracy of the approach for the classification of breast lesions based on the DCE-MRI and MRI methods. We intend to analyze brests using DCE-MRI, ADC mapping and 1H-MRS in combination with conventional methods and to resolve many technical issues. In addition, we want to study the possibility of increasing sensitivity and specificity of the presented method of integration of MRI, MRS, DCEI, ADC mapping and high-resolution histological analysis, to review all characteristics that enable a reliable diagnosis of breast lesions and thus to develop a non-invasive method for the early detection, diagnosis and monitoring of treatment of breast cancer.
Significance for science
Results of the project contributed new knowledge about nonivasive imaging diagnostic of breast lesions. This allows lower proportion of invasive diagnostic procedures in breast lesions, contributes to less stress od women in breast diagnostics and also lowers the costs of the breast lesions diagnostic. The scientific achievements of the project is proved also by the publications of the results in international literature. We emphasize the collaboration with the Dutch center from Nijmengen.
Significance for the country
This project resulted in new knowledge in breast lesions diagnostics that was developed in Slovenia and was published internationally. This knowledge will allow less stress full and more rational diagnostic of breast lesions. This is extremely important as find high numbers of nonpalpable breast lesions in the national mammographic screening program. Furthermore it contributed to our collaboration with a renowned center abroad. Our clinicians - researchers got knew knowledge and experience in scientific work. This project also allowed that an already established researcher could be employed in Slovenia thus contributing to our scientific environment.
Most important scientific results Annual report 2014, 2015, final report
Most important socioeconomically and culturally relevant results Annual report 2014, 2015, final report
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