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Projects / Programmes source: ARIS

Interaction motifs of specific binding of lipid A by peptides

Research activity

Code Science Field Subfield
1.04.02  Natural sciences and mathematics  Chemistry  Structural chemistry 

Code Science Field
P351  Natural sciences and mathematics  Structure chemistry 
Keywords
lipid A, peptides that bind lipid A, molecular recognition, NMR structural analysis
Evaluation (rules)
source: COBISS
Researchers (2)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  02566  PhD Jurkica Kidrič  Pharmacy  Researcher  1998 - 2001  233 
2.  12060  PhD Primož Pristovšek  Chemistry  Head  1998 - 2001  135 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  21,007 
Abstract
The molecular motifs of lipid A specific binding by peptides will be studied by molecular modelling refined NMR analysis of the isolated components and in complex. The peptides are analogues of polymyxin or fragments of lipid A binding proteins with solved X-ray structure. The results will contribute to the understanding of lipopolysaccharide recognition at the molecular level and will serve in structure based anti-septic drug design.
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