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Projects / Programmes source: ARIS

Regulation of gene expression by steroids in primitive eucaryots and the application of P450 gene technology in medicine

Research activity

Code Science Field Subfield
1.05.00  Natural sciences and mathematics  Biochemistry and molecular biology   

Code Science Field
P004  Natural sciences and mathematics  Biochemistry, Metabolism 
P320  Natural sciences and mathematics  Nucleic acids, protein synthesis 
Keywords
cytochrome P450, regulation, filamentous fungi, receptors, gene polymorphism, human cancer
Evaluation (rules)
source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  03079  PhD Katja Breskvar  Biochemistry and molecular biology  Head  1999 - 2001  189 
2.  08777  PhD Bronislava Črešnar  Biochemistry and molecular biology  Researcher  1998 - 2001  98 
3.  11711  PhD Vita Dolžan  Biochemistry and molecular biology  Researcher  1998 - 2001  761 
4.  18847  Marjan Kužnik    Researcher  2000 - 2001 
5.  02934  PhD Helena Lenasi  Biochemistry and molecular biology  Researcher  1996 - 2001  78 
6.  07085  PhD Tomaž Makovec  Biochemistry and molecular biology  Researcher  1999 - 2001  48 
7.  01989  PhD Janez Preželj  Metabolic and hormonal disorders  Researcher  1996 - 2001  303 
8.  08750  PhD Zvonimir Rudolf  Oncology  Researcher  1996 - 2001  257 
9.  07086  Savica Soldat    Researcher  1999 - 2001 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  15,391 
2.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,723 
3.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  47,554 
Abstract
a. In filamentous fungi steroids induce various enzymes and enzyme systems. The mechanisms of gene expression regulation was studies on three different levels: on receptor level, on cAMP level and on gene level. Steroid inducible enzymes of hydroxylase systems were also studied. b. There are two important aspects of P450 enzymes in human metabolism: one is metabolism of endogenous substances like steroids and the other is metabolism of xenobiotics such as drugs and carcinogens. Mutations in CYP21 gene (steroid 21-hydroxylase) were studied in slovenian patients with polycystic ovary syndrom. Genetic polymorphism of CYP1A1 (aryl-hydrocarbon hydroxylase) was studied in order to evaluate susceptibility to lung cancer.
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