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Projects / Programmes source: ARIS

Bioaktivne snovi iz nižjih vodnih organizmov in njihov mehanizem delovanja (Slovene)

Research activity

Code Science Field Subfield
1.05.00  Natural sciences and mathematics  Biochemistry and molecular biology   

Code Science Field
P310  Natural sciences and mathematics  Proteins, enzymology 
P340  Natural sciences and mathematics  Lipids, steroids, membranes 
Keywords
Cianobacteria, cnidaria, sea anemone, marine sponge, microcystin, toxin, pore-forming toxin, cytolysin, alkylpyridinium polymer, anticholinesterase, inhibitor, lipid membrane, hemolysis, cytotoxicity.
Evaluation (rules)
source: COBISS
Researchers (11)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  15686  PhD Gregor Anderluh  Biochemistry and molecular biology  Researcher  1998 - 2001 
2.  01115  PhD Gojmir Lahajnar  Physics  Researcher  1996 - 2001 
3.  06994  PhD Peter Maček  Biochemistry and molecular biology  Head  2000 - 2001 
4.  18203  PhD Petra Malovrh  Cardiovascular system  Researcher  1996 - 2001 
5.  17422  Irena Pavešič    Researcher  2000 - 2001 
6.  06902  PhD Zdravko Podlesek  Biochemistry and molecular biology  Researcher  2000 - 2001 
7.  12278  PhD Maja Rupnik  Microbiology and immunology  Researcher  1996 - 2001 
8.  07736  PhD Bojan Sedmak  Biochemistry and molecular biology  Researcher  1996 - 2001 
9.  15328  PhD Kristina Sepčić  Biochemistry and molecular biology  Researcher  1999 - 2001 
10.  06905  PhD Tom Turk  Biochemistry and molecular biology  Researcher  2000 - 2001 
11.  11035  PhD Aleksander Zidanšek  Physics  Researcher  1996 - 2001 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0105  National Institute of Biology  Ljubljana  5055784 
2.  0106  Jožef Stefan Institute  Ljubljana  5051606000  18 
Abstract
Fresh and sea water organisms (cianobacteria, coelenterates, marine sponges) are screened for toxins using bio-assays, and cholinesterase inhibitors employing enzyme tests. In fresh water cianobacterial blooms, microcystins are determined and their levels correlated to ecological factors and abundance of photosynthetic algae. Mechanism of action of a wild-type and recombinant proteinaceous pore-forming toxin from the sea anemone Actinia equina and its mutants are studied using cells and artificial lipid membranes. Topology and kinetics of the toxin binding, insertion and pore formation are studied. Surface active and anticholinesterase compounds are isolated from marine sponges. Mechanism of anticholinesterase activity of 3-alkylpyridinium polymers isolated from the marine sponge Reniera sarai is studied using recombinant insect acetylcholinesterase. Their surfactant-like activity, e.g. hemolysis, is characterized as compared to that of low molecular surfactants.
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