Bioaktivne snovi iz nižjih vodnih organizmov in njihov mehanizem delovanja (Slovene)

Code

J1-7440 (C) - included in ARRS records

Head

PhD Peter Maček

Period

1/1/1996 - 6/30/2001

Science

Natural sciences and mathematics (8)
Medical sciences (2)
Other (1)

Reseacher status

Researcher (10)
Junior expert or technical associate (1)
Junior researcher (0)
Researcher/expert (0)
Private researcher (0)

Education

Doctor's degree (10)
Other (1)

Sex

Woman (4)
Man (7)

Status

Active (7)
Retired (4)

No. of publications

1–9 (1)
10–99 (1)
100–999 (9)

Projects / Programmes source: ARRS

source: ARRS

Bioaktivne snovi iz nižjih vodnih organizmov in njihov mehanizem delovanja (Slovene)

Research activity

Code	Science	Field	Subfield
1.05.00	Natural sciences and mathematics	Biochemistry and molecular biology

Code	Science	Field
P310	Natural sciences and mathematics	Proteins, enzymology
P340	Natural sciences and mathematics	Lipids, steroids, membranes

Keywords

Cianobacteria, cnidaria, sea anemone, marine sponge, microcystin, toxin, pore-forming toxin, cytolysin, alkylpyridinium polymer, anticholinesterase, inhibitor, lipid membrane, hemolysis, cytotoxicity.

Evaluation (rules)

source: COBISS

Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases

source: WoS

source: Scopus

source: COBISS

Researchers (11)

no.	Code	Name and surname	Research area	Role	Period	No. of publications
1.	15686	PhD Gregor Anderluh	Biochemistry and molecular biology	Researcher	1998 - 2001	935
2.	01115	PhD Gojmir Lahajnar	Physics	Researcher	1996 - 2001	356
3.	06994	PhD Peter Maček	Biochemistry and molecular biology	Principal Researcher	2000 - 2001	524
4.	18203	PhD Petra Malovrh	Cardiovascular system	Researcher	1996 - 2001	43
5.	17422	Irena Pavešič		Researcher	2000 - 2001	1
6.	06902	PhD Zdravko Podlesek	Biochemistry and molecular biology	Researcher	2000 - 2001	137
7.	12278	PhD Maja Rupnik	Microbiology and immunology	Researcher	1996 - 2001	643
8.	07736	PhD Bojan Sedmak	Biochemistry and molecular biology	Researcher	1996 - 2001	231
9.	15328	PhD Kristina Sepčić	Biochemistry and molecular biology	Researcher	1999 - 2001	699
10.	06905	PhD Tom Turk	Biochemistry and molecular biology	Researcher	2000 - 2001	603
11.	11035	PhD Aleksander Zidanšek	Physics	Researcher	1996 - 2001	346

Organisations (2)

no.	Code	Research organisation	City	Registration number	No. of publications
1.	0105	National Institute of Biology	Ljubljana	5055784	13,217
2.	0106	Jožef Stefan Institute	Ljubljana	5051606000	85,605

Abstract

Fresh and sea water organisms (cianobacteria, coelenterates, marine sponges) are screened for toxins using bio-assays, and cholinesterase inhibitors employing enzyme tests. In fresh water cianobacterial blooms, microcystins are determined and their levels correlated to ecological factors and abundance of photosynthetic algae. Mechanism of action of a wild-type and recombinant proteinaceous pore-forming toxin from the sea anemone Actinia equina and its mutants are studied using cells and artificial lipid membranes. Topology and kinetics of the toxin binding, insertion and pore formation are studied. Surface active and anticholinesterase compounds are isolated from marine sponges. Mechanism of anticholinesterase activity of 3-alkylpyridinium polymers isolated from the marine sponge Reniera sarai is studied using recombinant insect acetylcholinesterase. Their surfactant-like activity, e.g. hemolysis, is characterized as compared to that of low molecular surfactants.