Projects / Programmes source: ARIS

Identifikacija in potrditev novih kandidatnih metilacijsko specifičnih bio-označevalcev pri karcinomu debelega črevesja in danke (Slovene)

Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Evaluation (rules)
source: COBISS
Researchers (1)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  27704  PhD Nina Hauptman  Chemistry  Head  2015 - 2017  98 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  45,335 
Significance for science
This project considered a highly relevant scientific problem of discovering novel biomarkers for early detection of colorectal cancer. We have adopted a first-class research methodology in the field of bioinformatics, which has the potential to discover and predict novel genetic changes in diseases. Our results contributed to vast field of research on colorectal cancer. We were able to identify new methylation specific biomarkers, regardless of the colorectal cancer subtype, which could be beneficial in developing new diagnostic tools. Also, the bioinformatics approach, that I used as the project leader in this study, can be applied to other diseases, discovering novel biomarkers in various states of disease, like precancerous lesions. This project contributes greatly to overall scope of the research of the central program group.
Significance for the country
This project is highly relevant for development of Slovenian science, it contributes to health care and has potential possible application in industrial research. This project enriches Slovenian research with high-impact knowledge. Bioinformatics methods are important and have high-value knowledge, which are becoming a necessity in the field of genetics, due to the technological advances made in recent years. Secondly, the project brings results in the medical health care field. Our results could help with more accurate tissue diagnosis, and in future, to help the clinicians make the diagnosis based on blood samples as a non-invasive and cost-effective diagnostic approach. Apart from direct application for science, this project has also possible applications for industrial research. The results of our project could be a starting point for industrial research and can lead to novel diagnostic tests. The results of the project are a starting point for new opportunities for collaboration in this research field.
Most important scientific results Final report
Most important socioeconomically and culturally relevant results Annual report 2015, final report
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