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Projects / Programmes source: ARRS

Membrane biophysics - structure, dynamics and transport as studied by epr methods

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Research activity

Code Science Field Subfield
1.02.01  Natural sciences and mathematics  Physics  Physics of condesed matter 

Code Science Field
P260  Natural sciences and mathematics  Condensed matter: electronic structure, electrical, magnetic and optical properties, supraconductors, magnetic resonance, relaxation, spectroscopy 
B120  Biomedical sciences  Molecular biophysics 
Keywords
electron paramagnetic (spin) resonance, spin probes, spin labels, membranes, lipoproteins, liposomes, genosomes, nanoparticles, free radicals, spin traps
Evaluation (rules)
source: COBISS
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (4)
no. Code Name and surname Research area Role Period No. of publications
1.  08742  Marjanca Nemec    Researcher  2000 - 2001  81 
2.  03070  PhD Slavko Pečar  Natural sciences and mathematics  Researcher  1998 - 2001  415 
3.  00393  PhD Milan Valter Schara  Natural sciences and mathematics  Researcher  1998 - 2001  343 
4.  01119  PhD Marjeta Šentjurc  Natural sciences and mathematics  Principal Researcher  1998 - 2001  511 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  85,872 
Abstract
Structure and function of biological membranes will be investigated as well as the interaction of biologically active substances and liposomes - vectors for the targeted delivery of drugs, with cells and tissues. The method is based on the semi- or non-destructive investigation of membranes and interactions in cells and tissues in situ and in vivo. In this project we will study membrane transport, binding and partitioning of hydrophobic molecules, mechanisms of formation of free radicals, the reactive intermediates important in series of biologically relevant lipid transformations, as well as the conformation of proteins and lipid-protein interactions in lipoproteins. The influence of lipid composition in liposome membranes as well as their size and lamelarity on the liposome stability and their interaction with cells and tissues will be also investigated. This will contribute to better understanding of the mechanism of action of membranes and their interactions with biologically active molecules and to the development of the methods for more rational transfer of drugs to the desired place in the cell or organism.
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