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Projects / Programmes source: ARIS

Načrtovanje in sinteza novih inhibitorjev beta-laktamaze (Slovene)

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Research activity

Code Science Field Subfield
1.09.00  Natural sciences and mathematics  Pharmacy   

Code Science Field
P310  Natural sciences and mathematics  Proteins, enzymology 
P390  Natural sciences and mathematics  Organic chemistry 
Keywords
beta-lactamase inhibitors, rational drug design, synthesis and biological testing of new chemical entities (NCE)
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (6)
no. Code Name and surname Research area Role Period No. of publications
1.  06065  PhD Anton Čopar  Chemistry  Researcher  1999 - 2001  63 
2.  04652  MSc Borut Furlan  Chemistry  Researcher  1998 - 2001  99 
3.  09179  PhD Alenka Hribar-Kikelj  Chemistry  Researcher  1996 - 2001  27 
4.  09905  PhD Darko Kocjan  Chemistry  Researcher  1999 - 2001  167 
5.  18316  PhD Lovro Selič  Chemistry  Researcher  1996 - 2001  79 
6.  01661  PhD Tomaž Šolmajer  Chemistry  Head  1998 - 2001  380 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0258  Lek Pharmaceutical Company d.d.  Ljubljana  1732811  8,438 
Abstract
We use the rational drug design approach to develop novel inhibitors of beta-lactamase enzymes which are the most common cause for resistance of bacteria towards beta lactam antibiotics. This is an interdisciplinary project which comprises drug design by the use of theoretical computational methods, organic synthesis, enzyme kinetics and structure determination by use of NMR spectroscopy and protein crystallography.
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