Laser photocoagulation is used to treat neovascularization-triggered diseases. As it lacks a dose control it can be inefficient or too disruptive. One of the main tasks of this project was to address and improve this. We improve this by blood coagulation stage detection via various fluorescence approaches in particular by spectral analysis of the fluorescence light, emitted from background, where some of the light is absorbed in blood components. Later on, we have filled in PCT patent application (see also COBISS-ID 31223079 and the socio-economic achievement 1) in which we have explained complete processing of the fluorescence spectral.
COBISS.SI-ID: 30682919
In the first paper, we have developed methods of the submicron characterisation of transient heat-transfer processes and the corresponding processes at the interface of boiling micro bubbles. Afterwards, we have transferred this expertise to the ophthalmology to enable detection of thermal-induced tissue changes via thermal imaging of the temperature field underneath a growing bubble. In this case the bubble did not occur due to nucleate boiling but due to energy release from laser pulse. Fluorescence microspectroscopy have been employed for this detection as well as associated sprectral analysis methods.
COBISS.SI-ID: 14672155
We described the autofluorescence changes occurring in the course of traumatic choroidal rupture using SD-OCT imaging. Hyper-autofluorescent rim, could represent the RPE hyperplasia during the resolution of choroidal rupture, that leads to lipofuscin build-up and more increased auto-fluorescence. Autofluorescence imaging is useful to show the area of post-traumatic RPE damage and healing in traumatic choroidal rupture.
COBISS.SI-ID: 4954028
Prospective comparative study was designed to assess the effect of surgical oxidative stress on diabetic retina in diabetic patients without diabetic retinopathy. Preoperative eye exam, best corrected visual acuity (BCVA), and optical coherence tomography (OCT) were followed by standard cataract surgery. The follow-up visits at 1, 3, and 6 months postoperatively included BCVA, OCT and microperimetry, to analyze changes between group of diabetic patients without diabetic retinopathy and group of nondiabetic patients. Based on the results of the study it was concluded that underlying diabetes does not influence the surgical outcome in diabetic patients without diabetic retinopathy. However, slight thickening of wider macula and corresponding decrease in retinal sensitivity observed in diabetic patients 6 months postoperatively might influence visual function on long term. The paper entitled PREDICTING VISUAL OUTCOMES OF SECOND EYE VITRECTOMY FOR PROLIFERATIVE DIABETIC RETINOPATHY (authors: Marko Šulak, Mojca Urbančič, Mojca Globočnik Petrovič) has been published in RETINA The Journal of Retinal and Vitreous Diseases (IF 3,039) in 2017. Predictive factors for visual outcome in the second operated eye of patients undergoing bilateral vitrectomy for complications of proliferative diabetic retinopathy were investigated in this study. Understanding the risk factors for advanced diabetic retinopathy is crucial for better patient management and improvement of treatment results.
COBISS.SI-ID: 3598764
In this study we investigated the structural organization of the lens epithelial cells, in particular their basal side which is in contact with the basal lamina. Three techniques, SEM, TEM and confocal microscopy have been employed, each of them showing the same morphological features, the extensions and the entanglements of the epithelial cells cytoplasmic membrane at the border with the capsule. This knowledge was then used to enable handling of the retinal epithelial cells while searching the effect of the laser light through the (micro)spectral detection.
COBISS.SI-ID: 2628780