A novel multi-layered wound dressing, composed of alginate, viscose and PET, with incorporated drugs from two different pharmacodynamic groups, for the treatment of painful wounds, is presented. A microporous PET mesh with incorporated fast-acting local anesthetic lidocaine was chosen as the layer in direct contact with the skin, and as such enables an immediate pain relieving effect, caused by wound care itself (e.g. during dressing changes). Pain relieve for the period until dressing change was achieved through incorporation of a nonsteroidal anti-inflammatory drug diclofenac into the second alginate and third viscose layers. The latter serves as a reservoir for diclofenac, as well as enables fine tuning of the dressings wound healing performance (e.g. air permeability, water retention…). The macroporous PET enables an unhindered absorption of the wound exudate into the alginate layer, which also maintains a moist wound environment. The novel dressing was analyzed in respect of the desired wound care related parameters (e.g. water retention, air permeability…), and in regard of the structural properties and morphology (e.g. contact angle measurements, IR spectroscopy, SEM). Finally, in vitro drug release testing was performed, followed by biocompatibility studies using human skin derived fibroblasts (e.g. Live/Dead and MTT assays).
COBISS.SI-ID: 4001452