The present study reports one of the few cases in which organophosphate (OP) and pyrethroid (PYR) pesticide human exposure is evaluated in family contexts by the analysis of mother/child pair samples. Urinary concentrations of 6 organic metabolites of organophosphates and 2 pyrethroids were measured in mothers and their 7-to 8-year-old children (n=168) in a general population from the central area of Slovenia. The most abundant OP metabolite in children was 4-nitrophenol (PNP) (median 0.7 ng/ml) and in mothers (0.45 ng/ml), representing parathion exposure. 3-Phenoxibenzoic acid (3-PBA) (0.26 ng/ml), the general metabolite of pyrethroids, and 3,5,6-trichloro-2-pyridinol (TCPY) (0.16 ng/ml; chlorpyriphos) were the second most abundant compounds in children and mothers, respectively. The geometric mean specific gravity adjusted concentrations of OPs and PYRs were statistically significantly higher in children than in their mothers (between 3% and 24% higher), with the exception of TCPY (26% lower). All OP and PYR metabolites found in higher concentration in children showed significant positive correlations with the metabolite concentrations found in the mothers (p ( 0.05 and 0.01), involving the fact that higher maternal concentrations were associated with higher children levels. These differential mother-children distributions and significant correlations were observed for the 2 types of pesticides studied, OPs and PYRs, which have different chemical properties. This agreement is consistent with the incorporation of the pesticides because of the general activities developed in the family context, instead of pesticide-dependent specific inputs. Comparison of the estimated daily intakes with the acceptable daily intakes of all detected metabolites revealed no significant risk of adverse health effects from exposure to these pesticides.
E.03 Other
COBISS.SI-ID: 32832807Expert chapter in the most important United Nations report: UNEP Global Mercury Assessment report 2019. In this monograph, the project team published three papers: PIRRONE, Nicola, HORVAT, Milena, KOTNIK, Jože, KINDBOM, Karin, AMOS, Helen M., OUTRIDGE, Peter, PARSMO, Rasmus, TELMER, Kevin, et al. Levels of mercury in air. V: Technical background report to the global mercury assessment 2018, (United nations environment programme/arctic monitoring and assessment programme). Tromso: AMAP/UNEP. 2019, str. 4-1-4-30. [COBISS.SI-ID 32594727] KOCMAN, David, WILSON, Simon, YARAMENKA, Katarina, KINDBOM, Karin, AMOS, Helen M., OUTRIDGE, Peter, PARSMO, Rasmus, TELMER, Kevin, HORVAT, Milena. Releases of mercury to the aquatic environment from anthropogenic sources. V: Technical background report to the global mercury assessment 2018, (United nations environment programme/arctic monitoring and assessment programme). Tromso: AMAP/UNEP. 2019, str. 6-1-6-16. https://wedocs.unep.org/bitstream/handle/20.500.11822/29831/gma_tech.pdf?sequence=1&isAllowed=y. [COBISS.SI-ID 32594215] kategorija: 3C (Z); tip dela je verificiral OSICN točke: 2.22, št. avtorjev: 9 BASU, Nilandri, HORVAT, Milena, EVERS, David C., ZASTENSKAYA, Irina, WEIHE, Pal, TEMPOWSKI, Joanna. Mercury levels and trends in human populations worldwide. V: Technical background report to the global mercury assessment 2018, (United nations environment programme/arctic monitoring and assessment programme). Tromso: AMAP/UNEP. 2019, str. 9-1-9-12. https://wedocs.unep.org/bitstream/handle/20.500.11822/29831/gma_tech.pdf?sequence=1&isAllowed=y. [COBISS.SI-ID 32594471]
B.06 Other
COBISS.SI-ID: 32594471HORVAT, Milena. HBM in Slovenia as a tool for exposure and risk assessments : presented at International Scientific Conference on Health and the Environment, 14-15 November, Minsk, Belarus. [COBISS.SI-ID 32913703] HORVAT, Milena. Human monitoring : biomarkers : Health and Environment Risk Imapct Assessment In the National System For Sound Chemicals Management Training Workshop, 11-13 November 2019, Minsk, Belarus. [COBISS.SI-ID 32914215] HORVAT, Milena. Human monitoring : ethical considerations : Health and Environment Risk Imapct Assessment In the National System For Sound Chemicals Management Training Workshop, 11-13 November 2019, Minsk, Belarus. [COBISS.SI-ID 32914471] HORVAT, Milena. Human monitoring : introduction : Health and Environment Risk Imapct Assessment In the National System For Sound Chemicals Management Training Workshop, 11-13 November 2019, Minsk, Belarus. [COBISS.SI-ID 32913959] HORVAT, Milena. Human monitoring : laboratory QA : Health and Environment Risk Imapct Assessment In the National System For Sound Chemicals Management Training Workshop, 11-13 November 2019, Minsk, Belarus. [COBISS.SI-ID 32914727] ZASTENSKAYA, Irina, HORVAT, Milena. Chemical safety, and biomonitoring : European Centre for Environmental and Health School, 31 October - 1 November 2019, Cornwal, GB. [COBISS.SI-ID 32830759] BASU, Nilardi, HORVAT, Milena, LEANER, Joy, MALM, Olaf, PACYNA, Jozef M., SAKAMOTO, Mineshi. GMOS : emerging issues and areas of uncertainty : presented at COP3 Specila event on Mercury Sciece, 27. November, 2019, Minamata, Japan. [COBISS.SI-ID 32925479]
B.04 Guest lecture