Type 1 diabetes is caused by autoimmune destruction of Langerhans islets' beta-cells, resulting in an absolute lack of one’s own insulin. Hence, individuals with type 1 diabetes require a life long intensive exogenous insulin therapy with glucose monitoring to prevent the development of diabetes-related complications, which can dramatically shorten their lifespan. The cause of type 1 diabetes is still unknown due to a lack of biomarkers and difficulties in gaining the insight into beta-cells functioning during the developmental stages of the disease. With their molecular cargo extracellular vesicles can modulate a target cell response and may affect the pathogenesis of the diseases. The extracellular vesicles containing miRNAs are often studied as disease biomarkers, but rarely as mediators of development of the disease. The role of extracellular vesicles derived miRNAs in type 1 diabetes is currently not well established. Our work aimed to evaluate the extracellular vesicles as biomarkers in type 1 diabetes and evaluate their role in the modulation of the immune system in the development of the disease.
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COBISS.SI-ID: 22023939