We have shown that organic compounds can be selectively and efficiently fluorinated in aqueous media. This achievement represents an original contribution and important breakthrough in organofluorine chemistry and a significant "greening" of these synthetic protocols, which have been for a long time been considered dangerous and risky. We published this work in Organic Letters, the highest ranked journal for original scientific papers in the field of organic chemistry.
COBISS.SI-ID: 18711079
We discovered that molecular iodine is an excellent catalyst for selective and efficient oxidation of ketones to gem-dihydroperoxides using 30% aqueous hydrogen peroxide. Geminal dihydroperoxides are the key precursors in the synthesis of various organic peroxides, up to now known methodes for their preparations are low yield and unselective. In a short period of time the publication has been sharing a considerably interest among scientific community.
COBISS.SI-ID: 19881255
In the article published in the leading journal for scientific accievements in the field of green chemistry we report the oxidative bromination of ketones using combination of H2O2-HBr in aqueous media. The reaction resulted in selective and efficient formation of alfa-bromo-substituted ketones, bromine atom economy was faund to be maximal, while for the isolation of final product any organic solvent was used. Publication have been for a month on the list of top-ten articles in Green Chemistry journal.
COBISS.SI-ID: 21186343
Prion diseases are fatal neurodegenerative diseases thought to arise from posttranslational conversion of normal cellular prion protein to a scrapie isoform. Experimental data suggest a role for copper(II) ions in the process. Ab initio QM/MM approach and available experimental data were combined in order to identify and evaluate three potential Copper(II) ion binding sites in the C-terminal portion of the normal cellular prion protein. Our results suggest that copper(II) ion binds to His 187 but not to His 140 and His 177 of the binding site in the cellular prion protein.
COBISS.SI-ID: 3858714
We were invited to contribute a chapter to the most comprehensive collection of scientific achievements in the field of synthetic organofluorine chemistry for which we prepared a complete review of the chemistry of N-F reagents from the group of N-fluoro-1,4-diazoniabicyclo(2.2.2)octane salts. This publication represents an indispensable and universal source of information of current research in the field of organofluorine chemistry. It was a great honour and recognition for us to participate in this publication.
COBISS.SI-ID: 19778855