The 1H and 19F NMR spectra revealed equilibria of seven species in the solutions of (C5Me4R)TiF3 (R ) H, Me, Et) from monomer to tetramer. The thermodynamics and kinetics of dimerization involving monomers and dimers allowed the prediction of the mechanisms of the processes. The equilibrium of monomer and dimer suggests that both monomer and dimer can be expected and helps in understanding the behavior of the catalysts and suggests catalysis with the more-active monomers. The catalytic system with partially resolved chiral ligands on titanium could achieve the chiral amplification.
The novel DNA cleavage properties of the highly water-soluble, square-planar [Cu(Hpyrimol)Cl] complex, together with the results of cytotoxicities toward selected cancer cell lines is reported. The copper complex cleaves X174 supercoiled DNA efficiently and shows high cytotoxicities toward L1210 murine leukemia and A2780 human ovarian carcinoma cancer cell lines that are sensitive and resistant to cisplatin. The IC50 values obtained for the copper complex in the sensitive cell lines are in the range of cisplatin.
X-ray diffraction was used to analyze the structure of Mo6S9-xIx nano-wires, that exhibit some interesting properties (extraordinary tensile strength along fibers). The wires were synthesized in another research programme group. As the material was new, the structure type had been unknown. Due to small dimensions and morphology, the structure determination was difficult. When the structure model was determined it was proven correct after checking with other methods, but can assess the feasibility of different models.
Collaboration with another programme group resulted in a structure determination, performed in our group, using powder diffraction, of a novel material for cathodes of lithium accumulators (isostructural Li2MSiO4, M=Fe, Mn). Solved structure enabled understanding and targeted change of the transport properties of the material (travelling of lithium ions along channels of hte octahedral interstices in the hexagonal closest packing of oxygen). After the structural model was determined, the computing methods were also applied.
In this systematic study of various vanadium(IV and V) compounds and their ability to stimulate glucose uptake by cells (insulin mimetic properties) were studied. No striking correlation between the nature of the ligand systems and the insulin-mimetic potency was found. Antibacterial quinolone was also used as a ligand. This interdisciplinary based work was highly cited in last period.