Antibiotics which interfere with DNA replication as well as cell wall synthesis induce the SOS response. We showed that the antibiotic cyprofloxacin induces synthesis of colicins, antibiotics with a narrow range of activity.
COBISS.SI-ID: 1509199
We determined a low prevalence of colicin K synthesis and a relatively high prevalence of ColE1 like plasmids. We showed that colicin K exhibits inhibitory activity against uropathogenic strains of Escherichia coli. A
COBISS.SI-ID: 1647695
The subglacial environment was considered as abiotic however, recently pshyrotolerant bacteria were found. Our group was the first to describe that this environemnt is also inhabited by eukaryotes, extromophile fungi. In subglacial ice with a sediment we discovered numerous species of Penicillium as well as melanized and non-melanized yeast. On the basis of biochemical and molecular characterization of arctic strains and strains isolated from conventional environments we determined that arctic isolates differ in their secondary metabolite profile.
COBISS.SI-ID: 1441161
A model of binding of two LexA protein dimers to the cka gene operator sequences was prepared. On the basis of a prepared mutant, gel shift and surface plasmon resonance experiments we showed that rotation of the DNA binding domain of the LexA protein is required. Our results will be the basis for preparation of new antimicrobial drugs.
COBISS.SI-ID: 1785423
When bacteria are exposed to a changing environment (for example salinity or temperature), it is likely that proteins are not active under all physicochemical conditions. Our results indicate that prokaryotes can survive extreme conditions by harboring two or more copies of a gene, each responsible for the same role, under different conditions.
COBISS.SI-ID: 1863247