Normal endothelial function is essential for the maintenance of normal blood vessel function and structure. It is known that endothelial function is impaired in patients with lacunar infarction (LI). This study has shown that treatment of patients with lipid- lowering medications significantly improved endothelial function.
COBISS.SI-ID: 21507801
S100B is a structural protein of astroglial cells, and it is released from the damaged cells. It may serve as a biochemical marker in acute carbon monoxide (CO)-poisoned rats. S 100B could also be used as a prognostic value in CO-poisoning instead of a subjective assessment. This study has shown that acute CO poisoning is associated with elevated S100B levels, which are better predictors of final outcome than the consciousness level. This finding is also important for the therapy planning in humans.
COBISS.SI-ID: 1587825
S100B can be used as a marker of brain injury caused by CO-poisoning. Here we used of S100B values for monitoring the effects of normobaric and hyperbaric oxygen therapy in conscious CO-poisoned rats. Results have shown that S100B levels remain elevated after treatment with ambient air or with normobaric oxygen. Only hyperbaric oxygen decreased levels of S100B, although all rats survived without any apparent consequences. This study has opened new questions: What kind of therapy is appropriate? Is it reasonable to use normobaric oxygenation before or instead of hyperbaric oxygenation?
COBISS.SI-ID: 21481433
Brain histology cannot be studied in CO-poisoned patients; therefore we evaluated the efficacy of normobaric versus hyperbaric oxygen therapy in preventing brain cell injury in CO-poisoned rats without loss of consciousness. Previous study has shown that only hyperbaric oxygenation reduces the blood concentration of S100B, but it remained unclear whether the damage of cells using other types of therapy is permanent or reversible. The results have shown that the normobaric oxygenation can also prevent permanent brain damage.
COBISS.SI-ID: 21495257
Neurovascular coupling can be studied by various methods: PET, functional MRI (fMRI), and possibly by transcranial Doppler (TD). A non-invasive and inexpensive assessment of neurovascular coupling would be of great importance. For this reason, we simultaneously studied graded responses of visually evoked cerebral blood flow velocity responses (VEFR) and visual-evoked potentials (VEP) to visual contrasts using EEG and TD. A significant association between the VEP and the VEFR has been found, meaning that TD can be used as an inexpensive and non-invasive assessment of neurovascular coupling.
COBISS.SI-ID: 18611929