The capillary network was studied in the rat soleus (SOL) and extensor digitorum longus (EDL) muscles after acute denervation and short lasting denervation. In EDL, the capillary course was parallel to the fibre axes, while in SOL it deviated from it, forming cross-connections among neighbouring capillaries. The length of capillaries adjacent to each individual muscle fibre (Lcap/Lfib) was clearly reduced in the SOL, while in the EDL it remained unchanged, although the muscle fibres significantly atrophied in both muscle types. When the SOL was reinnervated, Lcap/Lfib was completely restored.
COBISS.SI-ID: 20444889
Changes in the capillary network could reflect fibre type transformation provoked by acute denervation and short lasting denervation. We measured muscle fibre diameter, the length of capillaries per fibre surface area (Lcap/Sfib) and per fibre volume (Lcap/Vfib) in the rat extensor digitorum longus muscle and estimated the share of fibres expressing different myosin heavy chain isoforms and the share of the oxidative fibres. Higher values of Lcap/Sfib and Lcap/Vfib in denervated and reinnervated muscles reflected adaptation in fibre diameter and not transformation of fibre types.
COBISS.SI-ID: 23624921
Persistent muscle weakness observed in patients diagnosed for criticall illness myopathy could be at least partly a results of inhibitory effects of glucocorticoids on IL-6 secretion, which contributes to muscle regeneration at the level of mononuclear myoblast proliferation.
COBISS.SI-ID: 22260185
In collaboration with the group of SJ Burden from the New York University, Dr. Marko Jevsek discovered up to then unknown synaptic-specific protein CD24 which appeared to be important for the normal differentiation of the presynaptic part of the motor neuron in the process of neuromuscular junction formation.
COBISS.SI-ID: 2271551
It was demonstrated that aneural myotubes developed in the widely used experimental model of the C2C12 mouse muscle cell line reach high level of postsynaptic differentiation, which could never be observed in human myotubes unless they are innervated. It means that significant differences exist between humans and rodent species at the level of muscle development, which should not be neglected when results obtained on rodents are extrapolated to humans
COBISS.SI-ID: 25481945
It was demonstrated that aneural myotubes developed in the widely used experimental model of the C2C12 mouse muscle cell line reach high level of postsynaptic differentiation, which could never be observed in human myotubes unless they are innervated. It means that significant differences exist between humans and rodent species at the level of muscle development, which should not be neglected when results obtained on rodents are extrapolated to humans