1.

The essential role of the JAK/STAT1 signaling pathway in the expression of INOS in intestinal epithelial cells and its regulation by butyrate

NO (nitrogen oxyde) is a free radical playing important role in numerous physiological and pathophysiological processes. Its role in genesis, proliferation and apoptosis of tumor cells is proven, though not yet completely clarified. The study proved the protective action of butyrate and the involvement of NO signal pathway by means of JAK/STAT1 signaling pathway in this action.

COBISS.SI-ID: 22091737

2.

Fusion-related release of glutamate from astrocytes.

We proved that astrocytes posess mRNA and the proteins of secretory apparatus, needed for glutamate release. Subsequent experiments showed that astrocytes release glutamate, stored in the vesicles, by the process of calcium dependent exocytosis. It has been proven that, in addition to neurons, also glia cells significantly participate in neurotransmitter release and in intercellular communication in the central nervous system. The article is a result of collaboration of two Slovenian research groups and one from US.

COBISS.SI-ID: 17670617

3.

Prevention of microvesiculation by adhesion of buds to the mother cell membrane - A possible anticoagulant effect of healthy donor plasma.

The presence of microvesicles in the peripheral blood is associated with a higher risk for thrombosis. Certain plasma proteins could supress microvesiculation by mediating adhesion of the buds on the mother cell membrane. I the present work it was proven that that the a stronger adhesion to maternal maembrane is proportional with smaller risk for thrombosis.

COBISS.SI-ID: 23693785

4.

Properties of Ca2+-dependent exocytosis in cultured astrocytes.

Astrocytes as wel as neurons are capable of releasing different signalling molecules by regulated calcium ions-dependent exocytosis. The process is approximately about 100 times slower than the exocytosis occuring in neurons.

COBISS.SI-ID: 17672153

5.

Multiple role of histamine H1-receptor-PKC-MAPK signalling pathway in histamine stimulated nerve growth factor synthesis and secretion.

In this article the signaling pathway and the model of histamine interactions with different cytokines involved in histamine regulated release of nerve growth factor from different cell types (astrocytes, keratinocytes) were demonstrated. The publication is the consequence of the invitation of the organizer of the conference "Signal transduction pathways as therapeutic targets, Luxembourg 2006. Only 17 contributors out of 560 were invited to write a scientific article for a renown journal in the field of pharmacology (IF ) 3.0).

COBISS.SI-ID: 1085395