The authors examined if higher expression of acetylcholinesterase (AChE) in fast than in slow muscles was due to different patterns of activation of slow and fast muscles. Phasic activation of muscles maintained high expression of AChE, but tonic activation reduced it. This reduction was mediated via the calcineurin signaling pathway. Activation of this pathway suppresses AChE expression in rat muscles. This study revealed the synaptic plasticity in the neuromuscular junction.
COBISS.SI-ID: 22862553
We hypothesized that, associated with the state of anesthesia; there exist characteristic changes in both cardio-respiratory and cerebral oscillator parameters and couplings, varying with depth of anesthesia and the type of anesthetic. For anesthetic agents pentobarbital and ketamine-xylazine we observed two distinct phases of anesthesia, with a marked increase in vartheta-wave activity occurring on passage from a deeper phase of anesthesia to a shallower one. In other respects, the effects of the two anesthetics were very different.
COBISS.SI-ID: 22373081
In collaboration with colleagues from the Institute for Transfusional Medicine and National Institute for Chemistry, the properties of a new antibody V5B2 were analysed. We studied its binding characteristics in biochemical and immunohistochemical experiments with materials from normal human brains and from brains with prion protein plaques. We found that the V5B2 antibody showed high selectivity for pathologic form of prion protein and bound to it with high sensitivity. The results were published in an international journal with a very high impact factor.
COBISS.SI-ID: 2939930
The reasons for high failure rate after inferior alveolar nerve block in dentistry are not understood. The authors compared the effectiveness of three different anesthetics on the compound action potential of rat sensory nerve in vitro. Each of the anesthetic solution caused a complete disappearance of the compound action potential of the C fibers, but not of the A fibers. Articaine more effectively depressed the compound action potential of the A fibers than other anesthetics. This work substantialy contributes to the selection of appropriate anesthetic solution in dental procedures.
COBISS.SI-ID: 20186151
We investigated the effects of striatal dopamine depletion and the antiparkinsonic drugs on the striatal synaptotagmins (Syt). On the 6-OHDA-lesioned side we observed a nearly total loss of Syt I, IV, VII and XI mRNAs in the substantia nigra compacta (SNc). In dopamine-depleted striatum Syt II decreased and Syt X mRNA increased which could not be reversed by l-DOPA. Response to chronic striatal dopamine depletion involves complex changes in striatal Syt expression that are not reversed by antiparkinsonic treatment.
COBISS.SI-ID: 20748761