We conclude that rapid (turbulent) axially directed flow of plasma along non-occlusive blood clots causes forceful exchange of serum inside the clot with outer plasma which enhances both fibrin-specific and non-fibrin-specific lysis of fresh clots. Dissolution of non-occlusive retracted (aged) clots occurs only under fibrin-specific conditions combined with adequate transport of rt-PA into clots.
COBISS.SI-ID: 18174247
The effects of cerivastatin and fenofibrate on proteins involved in haemostasis and on markers of inflammation were investigated in otherwise healthy middle-aged males with combined hyperlipidemia. Cerivastatin had neutral effects on fibrinolysis, homocysteine or coagulation. On the other hand, fenofibrate increased PAI-1 antigen and activity and homocysteine, and did not affect coagulation. Both cerivastatin and fenofibrate reduced CRP levels, the decrease being significantly greater after cerivastatin. Fenofibrate also significantly decreased IL-6.
COBISS.SI-ID: 18764249
Warfarin is an anticoagulant drug with narrow therapeutic index and high interindividual variability in dose requirement. Multiple regression analysis demonstrated that CYP2C9 genotype, age, concomitant treatment with warfarin metabolism inducers and lean body weight contributed significantly to interindividual variability in warfarin dose requirement. The same factors, except for age, significantly influenced S-warfarin clearance.
COBISS.SI-ID: 1729649
Aspirin has been associated with adverse heart failure outcomes. Therefore, we hypothesized that clopidogrel when compared with aspirin would be associated with a slower progression of heart failure. Aspirin was associated with a greater increase in natriuretic peptides, implying that aspirin therapy is associated with a more progressive course of heart failure.
COBISS.SI-ID: 21585625
The author of the chapter is an expert in the field of research of early functional changes of the arterial wall in atherosclerosis. In this field he has published many studies in different international journals. Therefore, he was invited by the Editors to published in this scientific monography.
COBISS.SI-ID: 19036889