In this prospective, randomized, open-label, single-center study, we compared the efficacy and safety of two anti-interleukin-2 receptor monoclonal antibodies among adult recipients of at least 1 HLA-mismatched deceased donor renal grafts. Eligible patients were randomized to induction with either basiliximab or daclizumab. Patient survival was 98.4% with basiliximab and 96.7% with daclizumab, and graft survival was 96.8% versus 90.8%, respectively. No significant differences were observed between the groups.
COBISS.SI-ID: 24207065
This randomized clinical study sought to compare the anticoagulant effect of citrate using Ca-free dialysate and dialysate with Ca 1.25 mmol/L. Citrate anticoagulation with Ca-1.25 dialysate resulted in significantly worse anticoagulation of dialyzer and venous bubble trap compared with Ca-free dialysate, despite higher citrate dose.
COBISS.SI-ID: 24345817
Ventricular repolarization heterogeneity (VRH) is associated with the risk of arrhythmia and cardiac death. This study investigated the association between VRH and left ventricular mass (LVM). We found that greater LVM is associated with increased VRH in renal transplant recipients, providing a link with the high risk of arrhythmia and cardiac death, specifically in patients with decreased graft function.
COBISS.SI-ID: 24072153
This study was designed to compare the effects of a conventional lactate-based peritoneal dialysis (PD) solution (D) and a new biocompatible bicarbonate/lactate-based solution with a low concentration of glucose degradation products (P) on peritoneal ultrafiltration (UF) and other peritoneal membrane indices. This study shows that the daily UF with the P solution may be lower than with the D solution. Our results implicate that the peritoneal fluid absorption rate may differ between the two solutions.
COBISS.SI-ID: 3510705
This study compared the local peritoneal and systemic inflammatory effects of a conventional and a new biocompatible bicarbonate/lactate-based peritoneal dialysis solutions. Although there was a significant reduction in peritoneal IL-6 in patients using Bic/Lac solution, systemic levels of inflammatory markers did not differ. No changes were present in macrophage surface activation markers, suggesting less important role of peritoneal macrophages in the inflammatory process. The number of effluent macrophages was higher with Bic/Lac solution, contributing to improved intraperitoneal defense.
COBISS.SI-ID: 2235505