LK-157 is a novel tricyclic carbapenem with potent activity against class A and class C ß-lactamases. When tested against the purified TEM-1 and SHV-1 enzymes, LK-157 exhibited 50% inhibitory concentrations (IC50s) in the ranges of the clavulanic acid and tazobactam IC50s (55 nM and 151 nM, respectively).
F.02 Acquisition of new scientific knowledge
COBISS.SI-ID: 1374812Combination therapy of tricyclic carbapenems with different antibiotics has been patented.
F.02 Acquisition of new scientific knowledge
COBISS.SI-ID: 4059418Novel, unexpected antiarrhythmic activity of azaphenyllanine trmbin inhibitors has been patented
F.02 Acquisition of new scientific knowledge
COBISS.SI-ID: 24440025Improved affinity selection of ligands from phage-displayed libraries has been patented and the new approach enables serching fro new peptide ligands fro diverse molecular targets
F.02 Acquisition of new scientific knowledge
COBISS.SI-ID: 2271345Design, synthesis and evaluation of novel, non-statin cholesterol biosynthesis inhibitors has been described
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 2181233