This is a 3-year functional genomics STREP project. It aims to establish original tools for the systemic studies of cholesterol homeostasis and drug metabolism. These tools will be applied not only in basic research but also in applied research in new hypolipidemic drug discovery for Lek pharmaceuticals. The project includes 10 partners, from these 3 from Slovenia: from University of Ljubljana three faculties (MF, FE, FRI), SME company Crea, d.o.o. and Pharmaceutical Company Lek, d.d . (http://www.steroltalk.net)
D.01 Chairing over/coordinating (international and national) projects
The research of D. Rozman belongs to the field of biochemistry and molecular biology and in recent years as well functional genomics. Important international impact has achieved her works concerning regulation of steroid metabolism, particularly cholesterol and some steroid hormones. By introducing micorarray technology to the Slovenian research space and by producing an original DNA-microarray, D. Rozman importantly contributed to development of novel post-genome methods in Slovenia.
E.01 National awards
CFGBC consists of 16 institutions from academia, research and clinical institutions, together with pharmaceutical industry. The goal of CFGBC is to allow the Slovenian researchers and users the access to the modern infrastructure and knowledge of the po-genome technologies.
D.07 Presiding over a centre/laboratory
Together with Lek Pharmaceuticals we developed novel potential drugs for treatment of hyperchoelsterolemia in humans.
F.32 International patentCOBISS.SI-ID: 1349980
This is an international biannual meeting of scientists from the cytochrome P450 research field that was organized in Slovenia for the first time. The cytochromes P450 superfamily includes major drug metabolizig enzymes in mammals and also several endogenouse enzymes involved in cholesterol, bile acid, steroid hormones, vitamin D, etc., synthesis. The meeting hosted over 300 participants from 32 countries.
B.01 Organiser of a scientific meeting