MD-2 is a soluble protein involved in endotoxin (LPS) signalling via the TLR4 receptor. In this paper we showed that taxanes (paclitaxela and docetaxela) bind MD-2 and consequently inhibit LPS signalling. We also showed the most probable MD-2 - taxane binding modes and compared it with lipid binding.
COBISS.SI-ID: 4065818
The antimicrobial peptide PFWRIRIRR was produced in bacteria in the form of inclusion bodies. The solution structure of the peptide in SDS and DPC micelles is characterised by a well-defined short alpha-helix. The position of basic and apolar side chains indicates its positioning in the membrane that is also in agreement with characteristics of the peptide.
COBISS.SI-ID: 4071962