1.

A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation.

TLR3 recognizes RNA, which is characteristic for replication stage of several viruses. We have discovered the existence of additional RNA binding site at N-terminus. TLR3 dimerization requires binding of RNA to both binding sites which are separated by 50 A, which dictates the recognition of only longer segments of dsRNA. We have investigated the role of histidine and asparagine residues of the binding site.

COBISS.SI-ID: 3954714

2.

A comparative genomic analysis of calcium and proton signaling/homeostasis in Aspergillus species

Calcium and pH homeostasis in filamentous fungi have been identified using bio-informatics. Unique fungal protein, calcium ion channel, was determined that is not present in higher eukaryotes. The named protein could be used for drug targeting in higher eukaryotes. The named protein could be used for drug targeting.

COBISS.SI-ID: 4000538