In this invited review article in esteemed journal in the field of molecular endocrinology Dr. Lanišnik Rižner presented current theories on pathogenesis of endometriosis, followed by an overview on estrogen biosynthesis in normal and diseased endometrium. A model mechanism for increased formation of estradiol was presented separately for three different types of endometriosis. The interplay between estrogen action, inflamation and proliferation was described, and the estrogen metabolizing enzymes and receptors were discussed as novel therapeutic targets for treatment of endometriosis.
COBISS.SI-ID: 25555929
We examined inhibitory action of flavonoids, cinnamic acids and their derivatives against 17beta-HSD type 1. Several flavonoids are known as phytoestrogens, therefore, we examined their proliferative action in ER positive breast cancer cell line T-47D. Among 10 flavonoids 6 showed more than 70% inhibition at 6 micromolar concentration. In a series of 18 derivatives of cinnamic acid, the best inhibitor was 4-cyanophenyl 3,4-methylenedioxycinnamate, with more than 70% inhibition. None of flavonoids affected the proliferation of T-47D breast cancer cells.
COBISS.SI-ID: 24720601