Design, synthesis and SAR of LK-935 derivatives has been described and classification to subclasses according to sterol profile. Activity of novel original hypolipemics and comparision of activity with statins was described.
COBISS.SI-ID: 2235249
Construction and use of original low-density DNA microarray has been described and comparision with commercial high-density microarrays with correspondence to quantitative response on gene expression on cholesterol homeostasis.
COBISS.SI-ID: 23814361
Drug-interaction potential of LK-935, the novel non-statin type cholesterol lowering agent hase been investigated and comparision to statins made on primary hapatocytes.
COBISS.SI-ID: 24945625
The manuscript describes construction of gene regulatory networks with the Bayesian approach, on the basis of transcriptome results from human primary hepatocytes treated with hypolipidemic drugs.
COBISS.SI-ID: 24460249
We have prepared a soluble monomeric form of the bovine cytochrome P450 lanosterol 14a-demethylase (CYP51). Activity of bCYP51-d1 is similar to that of the recombinant human CYP51.
COBISS.SI-ID: 24225241