The influence of a series of independent variables on late cardiac damage in 211 long -term childhood cancer survivors in Slovenia was analyzed. Patients treated with radiation to the heart area are at the highest risk for injury to the valves.Patients treated with large doses of antracyclines or in combination with alkylating agents are at the highest risk of systolic defect and enlarged heart chambers,those treated with antracyclines are at highest risk of diastolic function.The time period of the patient's treatment 1989-98 has emerged as an important risk factor for injury of the heart.
COBISS.SI-ID: 21812007
The classification tree multivariate method was used on a group of 849 first cancer survivors, to identify childhood cancer patients with the greatest risk for development opf secondary neoplasms. The risk groups identified in our study are similar to the results of studies that used more conventional approaches. The usefulness of our approach is the friendly presentation of results that makes it attractive for further studies on larger samples.
COBISS.SI-ID: 22928089
The report presents an immunohistochemical expression study performed on 72 patients with Ewingsarcoma, using the tissue array method.The expression of CD99 ,CD117, p53 or bcl-2 has no statistical significant impact on survival. Patients age at the time at diagnosis and presense of tumor necrosis are the only significant prognostic factors in the study.
COBISS.SI-ID: 596859
Testicular and ovarian function were assessed in 24 female and 40 male long-term childhood cancer survivors, treated for Hodgkin's disease in Slovenia between 1972 an 1994 when 3-16 years old. Primary hypogonadism was found in 40(60%) males and 24 (25%) females. Not only radiation , but also alkylating agents and procarbazine alone caused damage of Leydig cells. Pelvic radiation in combination with chemotherapy is the most important risk factor for the development of primary hypogonadism both in males and females.
COBISS.SI-ID: 1002875
The survival of registry based data on 1827 children examined from 1957 to 2002 with follow-up ending 2007 were analyzed. The survival experience in Slovenia compares well with those of large samples in the United states SEER program 1975-1995 and the data collected by ACCIS from 62 population based cancer registries in Europe. The hazard of dying has been decreesing constantly , mainly due to improvements in leukemia treatment.
COBISS.SI-ID: 25676249