The aim was to evaluate HBO efficacy in reducing neuronal apoptosis in different time periods after CO exposure. In this study rats were exposed to CO and 100% oxygen at a pressure of three bar for 30 min 0-12 h after CO exposure. The apoptosis was evaluated by immunohistochemical analysis with antibodies against activated caspase-3. We found out that CO poisoning results in ganglionic cell apoptosis and that HBO has a time-dependent protective effect on CO-induced neuron apoptosis with the highest efficiency at 3 and 5 h after CO poisoning.
COBISS.SI-ID: 27454169
In this study we showed that the noradrenergic system plays an important role in controlling brain-derived neurotrophic factor (BDNF) production in these cells. We confirmed also that the synthesis is regulated by a dynamic interplay between alpha1- and beta1/beta2- adrenergic receptor mechanisms that converge at the level of transcriptional activation. The observed receptor crosstalk represents an adaptation to environmental insults in cases where NA signals become week and a convergence between signals becomes necessary for BDNF synthesis stimulation.
COBISS.SI-ID: 23055577
Astrocytes actively control neuronal activity and synaptic transmission and by producing various neurotrophic factors represent an important local cellular source of trophic support in the normal and diseased brain. Our results indicate for the first time that monoaminergic neurotransmitters play an important role in the regulation of NT-3 synthesis in cultured rat astrocytes.
COBISS.SI-ID: 26449369
In this article we presented that patients on a stable baclofen regime can develop baclofen toxicity due to acute renal failure. Haemodialysis removes baclofen as effectively as normal kidneys and it seems reasonable to use haemodialysis as a treatment modality in patients with accidental baclofen overdose due to acute renal failure.
COBISS.SI-ID: 23459801
The article about S10OB protein as a biochemical marker and prognostic parameter of brain damage that we used in CO-poisoned patients.
COBISS.SI-ID: 2245745