The overcome of endothelial barrier is a serious challenge in the treatment of brain tumors. Possible solution is delivery of drugs in liposomal carriers of adequate composition. For this purpose liposomes of different composition were prepared and influence of membrane fluidity on the uptake and transcytosis by endothelial (MDCK) cells, a model for blood brain barrier, investigated. The most pronounced transcythosis was obtained for liposomes composed of DPPC, cholesterol, DOPC and 20 mol% alkylphospholipid that experienced the highest membrane fluidity among the liposomes investigated
B.03 Paper at an international scientific conference
COBISS.SI-ID: 22514727Role of membrane domain structure in the interaction of liposomes with cell means a new scientific knowledge which will help in understanding of cell membrane interactions. In the study young scientists were included, who earned new practical knowledge and experience which will help in their future work.
F.01 Acquisition of new practical knowledge, information and skills
COBISS.SI-ID: 22164007