The prognostic significance of CD68 and kallikrein 6 for survival of brain cancer patients was inverstigated. We found that Kallikrein 6 was down-regulated in malignant glioma, but this differential expression did not have an impact on patient prognosis. In contrast, immunostaining of glioma tissue for CD68 and for cathepsin B may be used for prognosis of survival in these patients. This finding suggests that besides the known role of cathepsin B in invasion and angiogenesis, CD68 may be also associated with glioma progression.
Human mesenchymal stem cells (hMSC) are stem cells with proven immunomodulary effects on tomours. In co-culture conditions it was confirmed that glioma cells increase proliferation and invasion of hMSC, whereas hMSC have the opposite effect on glioma cells. The unravelling of mechanisms of these cells interactions are essential for developement new cell-based therapies.