Nanoparticle functionalization is the core method of present project. If a selected molecule is to be attached to a nanoparticle, the surface of the latter has first to be appropriately modified. In the present case we used silica nanocoatings. Within silica, another phase was incorporated (rhodamine 6G) with fluorescent properties. The methods developed in this preliminary study were used in further investigation.
COBISS.SI-ID: 4062490
In this second study, we started with magnetic nanoparticles (10 nm), coated them first with a silica nanocoating into which zinc atoms were embedded. The latter served as anchor points for coordinative binding of BSA (bovine serum albumin). The coordinative nature of binding and the reversibility of the binding process were proven using systematic SDS-PAGE anaylysis
COBISS.SI-ID: 3899162
First, SPION nanoparticles were coated with 1-2 nm thick silica coating that contained significant pore fraction. Into the pores of silica coating we incorporated up to 30% of model drug (naproxen). After imersion into test solution the drug was readily dissolved. The prepared composites could be of potential interest for use in diagnostics.
COBISS.SI-ID: 4191258
Incorporation of drug into (nano)porous carriers is one of the important strategies towards better control of drug release. It has been reported that in certain cases the incorporated drug is dissolved even faster than if dissolved in a free form. Using rigorous mathematical modelling we were the first to explain such peculiar enhancement of release from nanopores.
COBISS.SI-ID: 4339738
Authors tred to find new ways for prediction of coating efficiency by using only simple and often available experimental methods. Using a combination of the heterogeneous nucleation theory and contact angle measurement, they were able to develop a new way for prediction of coating efficiency and by that relieve the choice of proper coating materials. Such approach is especially important for the pharmaceutical industry in the field of taste masking and also for controlled modification of surface properties.
COBISS.SI-ID: 4529946