The synthesis of non-hepatotoxic cyclic peptides in cyanobacteria can mediate the release of various toxic and otherwise biologically active substances that induce systemic enotoxicity inmammals. In this paper, we present the procedure that gives a review of both toxic and non-hepatotoxic hydrophilic cyclic peptide production is important to and estimation of bioactive cyclic peptides in water environment.
The paper describes very selective peptidase inhibitory activities of the two main groups of non-hepatotoxic cyclic peptides, depsipeptides and ureido linkage-possessing peptides on serine peptidases. Planktopeptin BL1125 is a strong linear competitive tight-binding inhibitor of leukocyte and pancreatic elastase and also of chymotrypsin, whereas anabaenopeptins B and F show no inhibition of chymotrypsin, but inhibit both elastases. Relative selectivity and low cytotoxicity of the tested cyanopeptides suggest that they are potential candidates for therapy in inflammatory diseases and cancer.