Disclosed are novel ethylidene derivatives of tricyclic carbapenems, in the form of pure diastereoisomers and in the form of pure geometric isomers. Novel ethylidene derivatives of tricyclic carbapenems are used as inhibitors of the action of the enzyme beta lactamase and/or as antibiotics in human and veterinary medicine. Also disclosed are pharmaceutical formulations for the treatment of bacterial infections of human and animal organisms comprising as an active ingredient a therapeutically effective amount of an ethylidene derivative of tricyclic carbapenems in the form of an acid, a pharmaceutically acceptable salt or ester thereof and optionally in a combination with a beta lactam antibiotic, and usual pharmaceutically acceptable carriers and auxiliary substances. Also disclosed is a process for the preparation of novel ethylidene derivatives of tricyclic carbapenems.
F.32 International patentCOBISS.SI-ID: 2931482
Dr. Janežič is an Associate Editor of an International Scientific magazine Journal of Chemical Information and Modeling listed in the ISI Web of Science and possessing an impact factor.
C.04 Editorial board of an international magazine
A web server, ProBis, freely available at http://probis.cmm.ki.si, is presented This provides access to the program ProBis (Protein Bibnding Sites), which detect protein binding sites based on local structural alignments. Detailed instructions and user guidelines for use ProBis are available at the server under 'Help' and selected examples are provided under 'Examples'.
F.06 Development of a new productCOBISS.SI-ID: 4404506
The invention relates to a pharmaceutical composition comprising an ethylene derivatives of tricyclic carbapenems in the form of pure diastereoisomers and in the form of pure geometric isomers or a salt, ester or amide derivate thereof and an antibiotic and the use of this composition as a broad band spectrum betalactamase inhibitor
F.32 International patentCOBISS.SI-ID: 4059418