Within the research field of interactions and dynamics of multicellular systems, tissues and other complex systems, we tested the properties of a new MR imaging contrast agent based on ferrite nanoparticles . We have shown that ferriliposomes (ferrite nanoparticles encapsulated into the lipid vesicle) can be used as outstanding T2 MRI contrast agent what enable monitoring drug delivery to desired position by MRI detection. Furthermore, we confirm their use as a targeted drug delivery system to the specific site by external magnetic field in vivo improving the effectiveness of existing cancer treatments. With this study we were involved in the outstanding publication in the journal Nature nanotechnology. Since its publication the paper was cited 54 times (without autocitations).
COBISS.SI-ID: 25057831
We have studied the effects of switching of the gradient magnetic field on spin dynamics and on measurements of translational dynamics as obtained by the NMR methods. We have also shown a possibility for NMR tomography of samples in the weak Earth’s magnetic field, which is a significant contribution to the common effort of scientists to find a simple method of magnetic resonance imaging. With the editor’s invitation, these results were presented in one of the most prestigious journals in the field of NMR. The journal "Progress in nuclear magnetic resonance spectroscopy", where this paper is published, is the most prestigious journal in the field of nuclear magnetic resonance.
COBISS.SI-ID: 2157156
We developed a novel experimental technique to localize molecular information, provided by environment sensitive fluorescent probes, with microscopic spatial resolution. Bleaching correction and spectral fitting greatly improved the contrast for molecular imaging. An outstanding nanometre spectral peak position resolution was accomplished. In addition, the introduced approaches enable the use of photosensitive probes. The findings led to the publication of two papers in distinguished journals (Biomed Opt Express 2011 2:2083 and Opt Express 2013 21:25291). By the polarized fluorescence microspectroscopy we were able to measure angular dependent spectral and intensity variations which enable us to resolve coexisting molecular conformations in membranes and the interaction of the latter with advanced cancerostatic drug delivery formulations.
COBISS.SI-ID: 26970919
Electroporation is a phenomenon caused by externally applied electric field of an adequate strength and duration to cells that results in the increase of cell membrane permeability to various molecules, which otherwise are deprived of transport mechanism. An accurate coverage of the tissue with a sufficiently large electric field presents one of the most important conditions for successful electroporation. In the paper a method of monitoring the electric field during applications of electroporation pulses is presented. The method is based on a combination of current density imaging (CDI) and magnetic resonance electrical impedance tomography (MREIT). A good agreement between experimental and numerical results was obtained, suggesting that CDI and MREIT can be used to determine the electric field during electric pulse delivery and that both of the methods can be of significant help in planning and monitoring of future electroporation based clinical applications. As a result of this paper and longer collaboration, prof. Igor Serša was invited to Kyung Hee University in Korea as an international scholar.
COBISS.SI-ID: 8693332
Measurements of the temperature dependent molecular conformational space, which has been measured via electron paramagnetic resonance spectroscopy, enabled us to determine the internal molecular motional correlations and consequently the conformational entropy of molecules allowing molecular conformation recognition. The results have been published in the J.Phys.Chem.Letters and is considered as an excellent scientific achievement (IF=6.7).
COBISS.SI-ID: 28004647