To get better insight on the mechanism of antimicrobial action of flavonoides, the interaction of four flavonoides (kaemferol, kaemferol-3-glucoside,epigallocatechin and epigallocatechin-3-galate) with liposomes was investigated by EPR and fluorescence spectroscopy. All four flavonoiodes decrease membrane fluidity, what was reflected in the increased order parameter of the most ordered membrane domains. The most effective was epigallocatechin-3-galate that acts primarily on the water-lipid interface.
COBISS.SI-ID: 3725176
The concomitant effect of blood plasma flow and recombinant tissue plasminogen activator (rt-PA) on the degradation of retracted, non-occlusive blood clots in vitro was studied. It was shown that under the influence of fast tangential plasma flow, strong mechanical forces on the surface of a blood clot causing breakage of fragments of the clot. The size of removed fragments is highly dependent on blood flow velocity. Our hypothesis was that a faster tangential plasma flow removed larger fragments and resulted in faster overall thrombolysis.
COBISS.SI-ID: 23815719
By combining three different MRI techniques a new approach for accurately determining the gel layer thickness was developed. The method was used to study swelling dynamics of xanthan controlled release tablets.
COBISS.SI-ID: 2780273
It was found that NO suppresses water permeation through human erythrocyte membrane which is a consequence of nitrosylation of aquaporin-1 (AQP1) channel Cys189. The effect of •NO on Pd is discussed in terms of NO-induced vasodilation.
COBISS.SI-ID: 24290855
By comparison of experimentally derived and modelled spin-labelled side-chain rotational motional patterns we have determined the structure of the short-lived state of the C-terminal end of measles virus nucleoprotein in complex with phosphoprotein of the same virus, that represent replication switch. We have joined the site-specific mutagenesis and temperature-dependent EPR-detected motional anisotropies as well as modified modelling of the local rotational spaces based on reduced probabilities of individual rotamers due to coexistence of states within the EPR-spectroscopy time window.
COBISS.SI-ID: 23487783