Cytostatics are a broad group of mostly organic compounds possessing a diverse range of physico-chemical characteristics. The principles of their determination in environmental samples are similar to those applied to biological samples; though their presence in complex environmental matrices in trace amounts along with their structural diversity, make their determination a major challenge. This may justify the lack of data on occurrence, fate and degradation of cytostatic pharmaceuticals in the environment. Besides review on the existing literature dealing with the analysis of cytostatics in the environment, the scope of this work is to support the ongoing research in this field. This approach will require advanced sampling techniques and state-of-the-art analytical tools, including the latest separation methods and cutting-edge instrumentation.
COBISS.SI-ID: 24832295
Mercury (Hg) mining activities in Idrija, Slovenia, have resulted in significant contamination of local terrestrial environment. Due to the abundant precipitation, steep slopes and highly erodible underlying lithology, this region is especially prone to erosion. The objective of this study was to estimate mercury delivery to the receiving water body associated with the contaminated soil loss from the Idrijca River catchment draining the area of the mine. The total annual sediment yield of the catchment was calculated applying the Erosion Potential Method (EPM) in a Geographic Information System (GIS) environment. The results of this study can be used as an efficient tool for remediation interventions planning as well as to check the effects of management choices that would minimize the uncertainties in the process of decision-making.
COBISS.SI-ID: 24645671
A new analytical procedure for the fast separation of proteins from low molecular mass (LMM) compounds in human serum was developed. HiTrap desalting SEC column (isocratic elution with TRIS-HCl buffer, pH 7.4) coupled to ICP-MS enables separation of high molecular mass (HMM) from LMM species in serum in 10 min. To prove the reliability of the fractionation procedure developed, the protein peak and the LMM separated species were subjected to re-chromatography on CIM® DEAE-ICP-MS and FPLC - ICP-MS, respectively. The speciation data verified that during the fractionation on the HiTrap desalting SEC, no species transformation occurred. Due to the rapidness, sensitivity and reliability, developed analytical procedure is a promising tool for investigations of kinetics of Al binding to Tf and very suitable for studies of the efficiencies of the chelation therapies in patients overloaded with Al.
COBISS.SI-ID: 23978023