The study is focused on the formulation of colloidal delivery system composed of poly(lactic-co-glycolic acid) with incorporated cystatin and monoclonal antibodies attached on the surface. The target were cytokeratines expresed on the surface of breast tumour cells. Polymeric nanoparticles rapidly enter the targeted cells and release the inhibitor cargo within the lysosomes. The approach, which combines nanoparticulate delivery system with the inhibitory potential against extracellular and intracellular proteases, may improve efficacy of therapy in patients with breast tumours.
COBISS.SI-ID: 2620785
The chapter emphasises the importance of structural properties of microemulsions formed from ingredients having potential applicability in pharmacy. Different types and structures were identified by using complementary experimental techniques. Analysis of the data permits a qualitative description of the changes in the microstructures appearing in the microemulsion regime of the phase diagram, together with evidence for transitions between them. The chapter contributes an important basic knowledge about structural investigation of concentrated systems.
COBISS.SI-ID: 2507633
The aim of this study was to investigate if treatment response and the occurrence of adverse drug reactions are related with variability in leflunomide pharmacokinetics. The study included 71 patients with rheumatoid arthritis. In patients’ plasma samples active metabolite A77 1726 steady-state plasma concentrations were determined and nonlinear mixed effects modeling was applied. Apparent clearance of A77 1726 was significantly affected by genetic polymorphism of CYP2C19 and renal function. The obtained result proved to be clinical significant.
COBISS.SI-ID: 25801689
In the article several mathematical models were proposed to describe the kinetics of gastric emptying under fasting conditions. A double Weibull model was developed for describing various patterns of gastric emptying: immediate and rapid, delayed but rapid, delayed and slow, and emptying in several boluses with marked interruptions. In this manner, we could incorporate the kinetics of gastric emptying of pellets in the design of in vitro release experiments.
COBISS.SI-ID: 2517361
The aim of the study was to investigate the uptake of biological and small-molecule targeted oncology drugs by health systems in selected European countries (Austria, Croatia, France, Germany, Hungary, Italy, Slovenia and the UK) by the end of 2007. Uptake of targeted oncology drugs was assessed by using sales data as a marker of actual utilization. The targeted oncology drug market was growing substantially in all the selected countries from 1997 to 2007 and reached a 40% of oncology drug market.
COBISS.SI-ID: 2739057