Patent application describes Selenium containing modifying agents for site-directed pegylation to cysteines. Stabilizing effect is achieved while bond is cleavable in the presence of small amounts of reducing agent enabling release of fully active protein in blood.
New trinem antibiotics and inhibitors of beta-lactamases
Design, synthesis and evaluation of novel trinem compounds with antimicrobial activity
D.09 Tutoring for postgraduate studentsCOBISS.SI-ID: 2668913
Influence of pegylation of TNF-alfa analogues on pharmacokinetics and toxicity in laboratory mice and rats.
D.09 Tutoring for postgraduate studentsCOBISS.SI-ID: 3153274
At Next Generation Proteins conference organized by Informa we were invited to give presentation about current status and future perspectives of PEGylation of therapeutic proteins, where advantages and disadvantages of this technolgy were discussed.
B.04 Guest lectureCOBISS.SI-ID: 1423196