Patent application relates to Seleno-PEG reagents for site-specific PEGylation to cysteines. Stabilizing effect is achieved because bond is cleavable in the presence of small amounts of reducing agents enabling release of fully active protein in blood, environment with significant amount of reducing agent.
F.32 International patentCOBISS.SI-ID: 1518684
Patent application relates to pharmaceutical composition comprising an ethylene derivatives of tricyclic carbapenems in a form of pure diastereoisomers and in the form of pure geometric isomers or a salt, ester or amide derivate thereof and an antibiotic and the use of this composition as a broad band spectrum beta-lactamase inhibitor.
F.32 International patentCOBISS.SI-ID: 4059418