Article describes correlation between chromatographic behavoiur of series of well defined N-terminally pegylated IFN-alpha conjugates and their "in vitro" activity. We showed that lenght and shape of PEG reagent attached to the protein influence on retention times at CE-HPLC and based on CE-HPLC analysis it is possible to predict je "in vitro" biological activity of conjugates, which was not published before.
COBISS.SI-ID: 4143898
Article describes effect of replacement fluids saline, gelofusine, and blood on biochemical and hematological parameters in rats subjected to repeated blood sampling.
COBISS.SI-ID: 1416796
We performed comparison of 3 cytotoxicity screening assays and applied them for the selection of novel antibacterial hits
COBISS.SI-ID: 1413980
A flow cytometric method for determination of the blood neutrophil fraction in rats was established enabling monitoring of this blood parameter after drug administration for anticancer therapy
COBISS.SI-ID: 4115482
New high-throughput fluorimetric assay for discovering inhibitors of UDP-N-acetylmuramyl-l-alanine: d-Glutamate (MurD) ligase was established enabling faster screening of large number of samples for faster selection of candidate molecule.
COBISS.SI-ID: 1391196