Articles reviews PEGylation technology and its application for preparation of therapeutic proteins. It assesses advantages and limitations of PEGylation technology and highlights areas important for industrial production of biopharmaceuticals including assurance of quality, safety and efficacy of these products. Article was published in January 2010 and since then it has been cited 12 times, demonstrating its relevance.
Staphylococcus aureus is a highly adaptable human pathogen and there is a constant search for effective antibiotics. Fosfomycin is a potent irreversible inhibitor of MurA, an enolpyruvyl transferase that uses phosphoenolpyruvate as substrate. The goal of this study was to identify the pathways and processes primarily affected by fosfomycin at the genome-wide transcriptome level to aid development of new drugs.
In the present study the therapeutic efficacy of a colon-specific drug delivery system–LK-423 microcapsules–was examined in induced ulcerative colitis model in rats. On the histological level, the administration of LK-423 microcapsules resulted in most physiological regeneration of intestinal mucosa, what is probably related to local drug delivery near the site of inflammation achieved using microcapsules. These results demonstrate that LK-423 colon delivery microcapsules enhance the therapeutic efficacy of the drug and therefore appear to be a useful approach.
Despite intensive research in the field of oral anticoagulants over the last decade, simple and effective long-term prevention of thromboembolism is still an unmet need. Focus of the present review are drug delivery systems for anticoagulants. All relevant clinical trials with anticoagulants formulated in the oral DDS are reviewed, and selected preclinical examples of promising novel anticoagulant DDSs are also described.
Permanent implantation of vascular catheters allows multiple blood sampling from the experimental animal. The aim of the study was firstly to establish four cannulation procedures in rats, which will result in high rate of catheter patency after the post surgical recovery period and secondly to determine a suitability of food and water consumption (FC and WC) and body weight gain (BW) as markers for the estimation of the length of recovery period.