Many clinical trials in which individuals received one or more dietary antioxidants failed to demonstrate conclusive effects of antioxidant supplementation and in some cases the antioxidant therapy can even increase mortality. In this work, the idea is presented that antioxidants in their oxidative forms may have more health-beneficial effects than their reduced forms. It seems that it is not the anti-oxidative potential of the antioxidants that has the major role in health-improvement, but rather their involvement in cell signaling processes, regulation of transcription factor activities and other determinants of gene expression. Low concentrations of oxidized antioxidants may trigger an adaptive stress response (hormesis) and provoke an increased endogenous antioxidant protection and an activation of damage repair processes. Thus, if proved beneficial, the food supplements should contain also low to moderate concentration of specific antioxidants in their oxidized forms.
F.02 Acquisition of new scientific knowledge
COBISS.SI-ID: 4818283US patent: An analytical method and the executable computer program was developed for the analysis of the QT interval in the standard 12 lead ECG recording. The program works in realtime together with the Cardiax system (IMED, Budapest) and communicates interactively via internet with the server program Cardiosoft (Houston, Tx, USA), and is implemented by Cardiosoft as a part of the software package. (filed U.S. patent Cardiosoft).
F.32 International patent
COBISS.SI-ID: 28948953The authors have presented a new robot that can be used for the training of hemiparetics, which speedsup the recovery of muscle strength.
F.06 Development of a new product
COBISS.SI-ID: 7968852The book comprises all aspects of embriology imporant for the study of medicine.
C.02 Editorial board of a national monograph
COBISS.SI-ID: 255568640Successful aortic valve replacement in the setting of aortic stenosis leads todramatic improvements of the patient's dinical condition and wellbeing. Standard surgical aortic valve replacement is a relatively safe procedure in patients with low procedural predicted risk. Because of thoracotomy, cardiopulmonary bypass, aortotomy and difficult rehabilitation, the risk of possible complications, especially in the elderly, can be high. The treatment of symptomatic aortic steno si s in high risk patients has led to alternative pathways of treating symptomatic aortic stenosis. Balloon aortic valvuloplasty, as the first attempt of definite treatment of aortic stenosis, was not very successful because it yielded only short-term results. Research continued with balloon-expandable and self-expandable aortic valve prostheses that are deployed at the site of the native aortic valve using special applicators through the peripheral vessels. This procedure has its advantages and disadvantages compared to the conventional surgical procedure, but currentresults in selected high risk patients are comparable. With new knowledge, and improved technique and instruments, outcomes can be expected toimprove in the future.
F.21 Development of new health/diagnostic methods/procedures
COBISS.SI-ID: 26023641