The studies on animal vascular preparations have shown that alpha2-adrenoceptor activity interferes with the production of endothelium-derived nitric oxide (NO) that has been found to play an important role in the postocclusive reactive hyperaemia (PRH) response. We attempted to clarify the interference of the alpha-adrenoceptor activity with NO mechanism in the cutaneous PRH response in healthy humans. Our findings show that alpha2-adrenoceptor activity interferes with NO mechanisms in cutaneous microcirculation.
COBISS.SI-ID: 25860569
An increased sympathetic activity has been demonstrated to play an importabt role in the genesis of arrhytmias. Elevated cardiac sympathetic tone is observed during exposure to hypoxia. Therefore, we attempted to assess the direct influence of hypoxia on the autonomic control of the sinus node and ventricular myocardium in healthy non-acclimatized athletes. Our results indicate that hypoxia itself exerts an influence on the autonomic regulation of the sinus node and ventricles.
COBISS.SI-ID: 26050777
Although autonomic dysfunction was found in advanced Huntington's disease (HD) patients it is not clear whether there is autonomic dysfunction in presymptomatic and early symptomatic HD. Cardiovascular autonomic tests were performed in 14 presymptomatic HD mutation carriers (PHD), 11 early symptomatic HD patients (EHD) and in 25 sex and age matched controls. We found attenuated response to simple mental arithmetic test and exaggerated response to the late phase of cold pressor test. Our results suggest that subtle autonomic dysfunction occurs even in PHD and EHD.
COBISS.SI-ID: 26434521
K(ATP) channels play an important regulatory role in resting vascular tone and during hypoxia. Their role in endothelium dependent and independent vasodilatation in human skin microcirculation is less known. We aimed to clarify the role of K(ATP) channel blocker glibenclamide on acetilcholine induced endothelium dependent and sodium nitropusside induced endothelium independent cutaneous vasodilatation in healthy humans. Our findings show that K(ATP) channels play an important role in human cutaneous vasodilatation.
COBISS.SI-ID: 25860825
Several data from the literature suggest that caspase 3 is located in mitochondria, and will be dislocated to cytosol after activation of apoptosis. We have shown that the presence of caspase 3 in mitochondria can be shown only in preparations contaminated with erythrocytes. Our result is important for the understanding the steps in the apoptotic process.
COBISS.SI-ID: 25835993