Subtypes of SCC are SCCs, in which malignant cells exhibit diverse morphologic features, such as spindle or basaloid phenotype, gland-like structures, or papillae formation. The recognition of subtypes is important because of their prognostic implication. We proved that verrucous, spindle cell, basaloid and adenoid SCCs have different expression of desmosomal proteins in comparison to conventional SCC and normal squamous epithelium. Different profile of desmosonal proteins influences on cellular adhesion, differentiation, proliferation, invasion and metastatic potential.
COBISS.SI-ID: 27999449
In a recent study, we analyzed the expression of muscle and cardiac specific miRNAs (miR-1, miR-133a/b, and miR-208) in human myocardial infarction (MI). The expression analysis was performed on autopsy samples of infarcted heart tissue compared to healthy trauma victims and foetal hearts. The miR-208 up-regulation and miR-1 and miR-133a down-regulation was found in MI compared to healthy adult hearts. Furthermore, some patterns of miRNA expression were similar in MI and foetal hearts, supporting the concept of cardiac gene reprogramming in the remodelling of the heart.
COBISS.SI-ID: 516179993
GLUT-1 is a transmembrane glucose transport protein that allows the facilitated transport of glucose into cells. Overexpression of GLUT-1 has been detected in different carcinomas. We analysed GLUT-1 expression in different morphological stages of gallbladder carcinogenesis. While normal gallbladder mucosa lacked GLUT-1 immunoreactivity, a characteristic increase in the presence and staining intensity was observed from premalignant lesions to carcinomas. The results of our study show that overexpression of GLUT-1 has an important role in gallbladder carcinogenesis.
COBISS.SI-ID: 26240217
The aim of our study was to assess whether number of sections per block used in cervical excision biopsies of cervical tissue (either cold knife or large loop excision of transformation zone (LLETZ)) influences the finding of cervical cancer by histopathological examination. Our assessment showed that a method with a large number of levels per cervical cone or LLETZ biopsy did not increase sensitivity for the detection of cervical cancer. Extensive sectioning may need to be reconsidered.
COBISS.SI-ID: 516146457
International expert group developed a standardized scoring system for both disease-specific lesions, i.e. glycosphingolipid inclusions, and general lesions of renal disease progression, i.e. fibrosis and sclerosis. Pathologic lesions were observed in a spectrum of appearances already in early stage of Fabry nefropathy and were generally more intensive in males than females. The scoring system will be useful for assessment of prognosis and respone to therapy.
COBISS.SI-ID: 27108825