Prior to the beginning of treatment, 114 patients with B-cell lymphoma treated with rituximab and chemotherapy had CD20 expression assessed by quantitative flow cytometric measurements. Our data show that patients who achieved complete response after rituximab therapy had a significantly higher expression of the CD20 antigen (p=0.018) than those whose disease only stabilized after rituximab therapy. Patients with a CD20 expression level above the cut-off value treated with rituximab had a significantly longer overall survival than patients with a CD20 expression level below the cut-off value.
F.22 Improvement to existing health/diagnostic methods/procedures
COBISS.SI-ID: 988283In 43 MSI-H colorectal cancers we searched for new targets of promoter methylation, inspected the nature of methylation process, and the influence of methylation at specific CpG site on gene expression. CpG methylation was detected in 12 tumor suppressor genes. According to the detected methylation pattern, two groups of tumors, significantly differing in age, exist in MSI-H colorectal cancers.
F.22 Improvement to existing health/diagnostic methods/procedures
COBISS.SI-ID: 26558681The purpose of the study was to perform a national review of negative, low-grade and inadequate smears reported during the latest screening period before cervical cancer diagnosis in 2006, after the first 3 years of the screening programme. Altogether 37 patients with 59 smears (together with 118 control slides) were included in the review. Revision of smears has shown that twenty-one of 37 women also had high-grade cytology prior to diagnosis of cancer.
F.22 Improvement to existing health/diagnostic methods/procedures
COBISS.SI-ID: 478627Assessment of HER2 status is mandatory for the treatment of patients with invasive breast cancer. We tested 31 cases of primary or metastatic breast carcinoma with paired cytological and histological samples of the same tumour. In the four cell lines, the FISH protocol resulted in ratios that corresponded to the declared gene status. Analysis was successful in 27 (87.1%) cytospins and in 31 (100%) histological samples. As a conclusion, FISH is a reliable method for the determination HER2 gene status on cytological specimens.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 253296128From 2000 to 2009, 534 breast cancer patients underwent axillary lymph node dissection (ALND) due to metastatic SLN at our institution. Using logistic regression results three nomograms were created. Ultrasound examination of the axilla was a powerful independent variable for presence of non-SLN metastases. Other variables included were tumor size, lymphovascular invasion, metastasis size in SLN, number of negative and number of positive SLNs. Omission of completion ALND might be considered in patients with the probability of having non-SLN metastases of 10% or less.
F.22 Improvement to existing health/diagnostic methods/procedures
COBISS.SI-ID: 812667