Fine-needle aspiration biopsy (FNAB) is a non-invasive, simple and cheap procedure, which could serve for diagnostic purposes but also - simultaneously - for radiosensitivity testing. This we proved by immunocytochemical testing to p53, cyclin D1, stefin A and Ki-67 of FNAB cell samples of neck metastases from patients with head and neck carcinoma treated with concomitant chemoradiotherapy. Cyclin D1 and Ki-67 pair was identified as valuable marker for predicting regional response to radiotherapy, and might assist when deciding on the most appropriate primary therapy for the patient.
COBISS.SI-ID: 832635
In the majority of patients irradiated for early glottic cancer an abnormal voice was reported. In this paper the voice quality was assessed using subjective and objective (acoustic analyse, aerodynamic measurements) methods and the laryngeal function and morphology was evaluated by videolaryngostroboscopy. We confirmed that after successful irradiation, the great majority of the patients have at least a slightly hoarse voice. A better voice outcome could be achieved if radiotherapy was followed by the patient’s cessation of smoking and the appropriate voice therapy.
COBISS.SI-ID: 26211545
Perfusion computer tomography represents new, noninvasive and fast method which allows presentation of some physiological parameters in the area under investigation. In this research paper we succeeded as the first in the field to prove that perfusion CT monitoring in patients with squamous cell carcinoma of the head and neck treated with radiotherapy and cisplatin-based chemotherapy might be of predictive value for identifying tumors that may respond to cisplatin-based radiochemotherapy.
COBISS.SI-ID: 000000
In 2000, meta-analysis of MACH-NC collaborative group proved simultaneous – concomitant application of radiotherapy and chemotherapy as the most effective combination of the two modalities in head and neck cancer. In updated analysis 24 new trials were included (total – 93, with 17.346 patients), among others two randomized clinical studies of our program group. Results of updated analysis confirmed superiority of concomitant radiochemotherapy against all other combinations of irradiation and chemotherapy, including induction chemotherapy
COBISS.SI-ID: 904059
Postoperative radiotherapy (PORT) of regional metastases of melanom to the neck is not widely accepted mode of therapy. In this paper we compared treatment detailes and results in operated pateints and those who had PORT. We found out that PORT has the potential to compensate effectively for the negative impact of adverse histopatologic features to regional disease control and that the number of involved lymph nodes is proposed as an additional criterion for limiting the implementation of PORT. We recommend RT with 2-2.5 Gy/fraction and cumulative eqTD2)=60 Gy.
COBISS.SI-ID: 000000