This article describes the transforming potential of 7TM receptor BILF1 encoded in the open reading frame of the Epstein-Barr virus (EBV). BILF1 is regulated by the ?-herpes viruses and has an indirect role in viral pathogenesis. Mutagenesis data revealed that BILF1 and its alternative form of the DRY motif that is present in BILF1 are associated with receptor constitutive activity and its ability to mediate cell transformation in vitro and tumor formation in vivo. Results suggest that BILF1 could be involved in the pathologies of EBV.
COBISS.SI-ID: 3217018
The isolation, cloning and characterization of a new phospholipase A2 (PLA2) from the northern Pacific sea anemone, Urticina crassicornis (UcPLA2) is described. UcPLA2 lacks hemolytic and neurotoxic activities. In this study, we have provided some new insights into the possible origin, distribution, diversity, evolution and classi?cation of the metazoa-speci?c group I PLA.
COBISS.SI-ID: 23636263
The aim of our retrospective study was to determine significant differences of selected parameters between groups, divided according to the IFA titers (6 groups) and PCR positive result (one group) in attempt to improve current diagnostic and treatment criteria. Thrombocytopenia was the most prominent change in all positive dogs. There were significant differences only between each positive group compared to the control group. Our results showed the necessity of introducing additional diagnostic criteria in clinical practice to confirm the clinical relevance of exposure to A. phagocytophilum.
COBISS.SI-ID: 3296122
The effect of furosemide in the lung appears to be a reduction in transcapillary pressures and inhibition of the erythrocyte anion exchange, which may lead to attenuation of transpulmonary fluid fluxes during exercise. This was tested in exercising horses near maximal exercise. We expected that this will qualitatively affect the pressure in the pulmonary circulation and changed lung fluid dynamics. Cardiac output was reduced in after treatment with furosemide, but not after treatment with placebo. Therefore, furosemide does not appear to have a significant effect on transmural forces in lung.
COBISS.SI-ID: 3317626
Nitric oxide synthase (NOS) inhibitors are reported to protect against the local tissue damage in periodontal disease by reducing nitroxidative stress during inflammation. NOS inhibitors systemic effects were investigated in a murine chronic oral inoculation model using live P. gingivalis. Repeated ingestion of P. gingivalis resulted in generalized production of nitric oxide (NO) and nitrite/nitrate (NOx). Their formation was prevented by treatment with selective inhibitor of inducible nitric oxide synthase (1400W), while treatment with non-selective NOS inhibitor (L-NAME) was not effective.
COBISS.SI-ID: 3212666