Mir717 (mmu-mir-717) was first reported in mouse, residing in the intron 3 of Glypican 3 (Gpc3) gene. Our present study revealed that the microRNA (miRNA) gene is conserved among 26 mammalian species. Additionally, A)G substitution was identified in the seed region of Mir717 among different mouse strains. We also compiled a total of 197 genes potentially targeted by Mir717, including nine genes that are associated with obesity and related phenotypes in mammals.
COBISS.SI-ID: 2780808
We discovered that genomic region which was identified in previous experiments and exhibited effect of single locus consists of at least two closely linked loci Fob3b1 and Fob3b2. This result demonstrates the complexity of genetic architecture of quantitative traits and shows fractal nature of those loci, suggesting that such loci are composed of cumulative effects of the greater number of polymorphisms, which are closely linked.
COBISS.SI-ID: 2597000
The article offers a literature review in the field of transgenic models for cholesterol biosynthesis and critically analyzes plans and possible false interpretations for each individual animal model. The article will be useful for scientists, working in the field of biology of cholesterol biosynthesis,bur also for broader readership, not specialized in transgenesis.
COBISS.SI-ID: 2789256
Molecular data inferred from three nuclear DNA regions were used to re-examine the phylogenetic position and taxonomic status of former Phoxinellus taxa. Our results confirm a previous notion that the former genus Phoxinellus is not a monophyletic group but rather a grouping of independent lineages.
COBISS.SI-ID: 2740360
The genetic structure of Salmo dentex and its phylogenetic relations to sympatric salmonids in the Neretva and Skadar River basins were evaluated using mitochondrial DNA (mtDNA) control region, eight microsatellites, and somatolactin (SL) gene. We hypothesize S. dentex to be a particular life history form of S. marmoratus in the Neretva basin and of S. trutta in the Skadar basin. These results clearly demonstrate that S. dentex does not represent a monophyletic lineage and should not be considered a distinct species.
COBISS.SI-ID: 2635656