Fatty acid composition of red blood cells of patients with different disease states is analysed. Fatty acids are basic formers of cell membrane and thus they regulate the red cell surface deformability, flexibility, adhesion to other cells and immune recognition. The study demonstrates feasibility of data analysis in discrimination of patients with different diseases according to fatty acid profile and reports considerable differences in membrane fatty acid profiles in patients with various disease states, such as inflammatory bowel disease, uterine leiomyoma or colon adenomas.
COBISS.SI-ID: 14417942
pKa is one of the major factors in the interactions of proteins with molecules having weakly acidic or basic groups. We calculated pKa of several carboxiclic acids including bilirubin in the view of its transport trough the cell membrane by bilitranslocase using quantum chemical calculations in conjunction with Langevin dipoles and solvent reaction field method of Tomasi and coworkers. We demonstrated that the calculated pKa values for formic acid, acetic acid, nicotinic acid and bilirubin compare well with the experiment if flexible basis sets and Langevin dipoles solvation model are used.
COBISS.SI-ID: 4355610